Publicado

2008-10-01

Administración de insulina por vía intranasal y memoria declarativa. Revisión sistemática de la literatura

Intranasal insulin administration and declarative memory. A systematic review

Palabras clave:

insulina, memoria, administración intranasal, enfermedad de Alzheimer, MEDLARS, literatura de revisión como asunto. (es)
Insulin, memory, administration intranasal, Alzheimer disease, MEDLARS, review literature as topic. (en)

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Autores/as

  • Andrés Jagua Gualdrón Facultad de Medicina, Universidad Nacional de Colombia, Bogotá.
  • Vladimil Ávila Ávila Médico Cirujano
Antecedentes. La insulina participa de los procesos de formación de la memoria y los defectos en su señalización podrían estar relacionados con el déficit cognitivo y las enfermedades neurode-generativas como la enfermedad de Alzheimer.
Objetivo. Evaluar la relación entre la administración de la insulina por vía intranasal y la memoria declarativa en estudios en humanos.
Material y métodos. Se realizó una búsqueda intensiva y sistemática de estudios publicados entre enero de 1997 y diciembre del 2008 a través de las bases de datos MEDLINE, Cochrane, DynaMed y LILACS. Los estudios fueron sometidos a dos pruebas de calidad metodológica, se les realizó un análisis crítico y se aplicó estadística básica.
Resultados. Se hallaron cinco artículos que incluían 252 personas. De ellos 143 tenían diagnóstico probable de la enfermedad de Alzheimer o alteración cognitiva leve. Los estudios reportan mejoría en las tareas de la memoria a corto y largo plazo en los grupos que recibieron la insulina comparados con quienes recibieron el placebo.
Conclusión. Los estudios son pocos y difíciles de comparar. Sin embargo tras este análisis puede sugerirse que la insulina actúa durante la formación de la memoria declarativa y podría emplearse en el tratamiento de los trastornos de la memoria.
Background. Insulin acts in memory formation and its signal impairment can be related with mild cognitive impairment and neurodegenerative diseases like Alzheimer's disease.
Objective. To evaluate the relationship between intranasal insulin administration and declarative memory in studies with human.
Materials and methods. A systematic search of studies published from January 1997 to december 2008 through electronic databases MEDLINE, DynaMed, Cochrane and LIlACS. Articles were evaluated with two tests for methodological validity and a basic statistical analysis was performed.
Results. We find five articles that include 252 persons. 143 have presumptive diagnosis for Alzheimer's disease or mild cognitive impairment. Studies reported improvement in short and long term memory task in people that receive insulin compared with placebo.
Conclusion. Studies are few and difficult to compare. However, analysis of the articles suggests insulin play some roles in declarative memory formation and in the future, insulin can be a treatment for cognitive disorders.

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Citas

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Derechos de autor 2008 Revista de la Facultad de Medicina

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Esta obra está bajo una licencia Creative Commons Reconocimiento 3.0 Unported.

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