Propuesta de un protocolo de electro-estimulación para el tratamiento de úlceras por presión grado II y III
Proposal of electrical stimulation protocol for the treatment of pressure ulcers grade II and III
Palabras clave:
Úlcera por Presión, Estimulación Eléctrica, Cicatrización de Heridas, Electrofisiología (es)Pressure Ulcer, Electric Stimulation, Wound Healing, Electrophysiology (en)
Antecedentes. El uso de estimulación eléctrica como terapia ayudante para la curación de heridas se remonta al año 1700. No obstante, a pesar de los avances científicos del siglo XX solo se conocen estudios experimentales hacia la década de los 70, cuando se inicia un proceso investigativo con el fin de conocer a mayor profundidad las propiedades eléctricas de la piel y el efecto que tiene la estimulación eléctrica en las reacciones fisiológicas de las células epidérmicas para aumentar y favorecer la curación de heridas.
Objetivo. Proponer un protocolo de electro-estimulación para el tratamiento de úlceras por presión grados II y III, con base en la mejor evidencia reportada.
Materiales y métodos. Búsqueda de artículos en diferentes bases de datos utilizando los títulos de términos médicos (Medical Subjects Headings) MESH, con la utilización de los vocablos "Wound Healing", "Pressure Ulcer" y el sub encabezado "Electrophysiology" y "Electrical Stimulation".
Resultados. Después de realizar el análisis de la información se presenta la fundamentación de los parámetros que contiene la propuesta del protocolo (tipo de corriente, forma de onda, intensidad, campo eléctrico, frecuencia); se sustenta el cambio de polaridad, ubicación de electrodos y tiempo de tratamiento.
Conclusión. Ante la heterogeneidad de parámetros en la aplicación de electro-estimulación en el proceso de cicatrización de úlceras por presión, se propone desde la evidencia, un protocolo de electro-estimulación fundamentado en los procesos biológicos, eléctricos y mecánicos de la piel.
Background. The use of electrical stimulation as adjuvant therapy for wound healing dates back to 1700. However, despite the scientific advances of the twentieth century, experimental studies are known only since the 70s, when research process were initiated in order to study the electrical properties of the skin and the effect of electrical stimulation physiological responses of skin cells to enhance and promote wound healing.
Objective. To propose a protocol of electrical stimulation for the treatment of pressure ulcers grade II and III, based on the best evidence reported.
Materials and methods. Research of articles in different databases using the titles of medical terms (Medical Subject Headings) MESH, with the use of the words "Wound Healing", "Pressure Ulcer" and the sub-heading "Electrophysiology" and "Electrical Stimulation".
Results. The analysis of the information presented substantiation of the parameters contained in the proposed protocol (AC, waveform, intensity, electric field frequency) underlying the change in polarity, electrode location and time treatment.
Conclusion. Given the heterogeneity of parameters in the application of electrical stimulation on the healing process of pressure ulcers, an electro-stimulation protocol is proposed based on biological processes, electrical and mechanical skin.
Descargas
Citas
Wassermann E, van Griensven M, Gstaltner K et al. A chronic pressure ulcer model in the nude mouse. Wound Repair Regen. 2009;17(4):480-4.
Falanga V. Chronic wounds: pathophysiologic and experimental considerations. J Invest Dermatol. 1993;100(5):721-5.
Niitsuma J, Yano H, Togawa T. Experimental study of decubitus ulcer formation in the rabbit ear lobe. J Rehabil Res Dev. 2003;40(1):67-73.
Peirce S, Skalak T, Rodeheaver G. Ischemia-reperfusion injury in chronic pressure ulcer formation: A skin model in the rat. Wound Repair Regen. 2000;8:68-76.
Ojingwa J, Isseroff R. Electrical stimulation of wound healing. J Invest Dermatology. 2003;121:1-12.
Shaw T, Martin J. Wound repair at a glance. J Cell Sci. 2009;122:3209-13.
Velnar T, Baley T, Smrkolj V. The wound healing process: an overview of the cellular and molecular mechanisms. J Int Med Res. 2009;37:1528-42.
Edelberg R. Relation of Electrical Properties of Skin to Structure and Physiologic State. J Invest Dermatology. 1977;69:324-7.
Jankovic A, Binic I. Frequency rhythmic electrical modulation system in the treatment of chronic painful leg ulcers. Arch Dermatol Res. 2008;300(7):377-83.
Griffin J, Tooms R, Mendius R et al. Efficacy of high voltage pulsed current for healing of pressure ulcers in patients with spinal cord injury. Phys Ther. 1991; 71(6):433-42.
Kloth L, Feedar J. Acceleration of wound healing whith high voltage monophasic pulsed current. Phys Ther. 1988;68(4):503-8.
Reilly J. Applied biolectricity: from electrical stimulation and electrophatology. 2da ed. New York (Estados Unidos): Springer; 1998.
Houghton P, Campbell K, Fraser C et al. Electrical Stimulation Therapy Increases Rate of Healing of Pressure Ulcers in Community-Dwelling People With Spinal Cord Injury. Arch Phys Med Rehabil. 2010;91:669-78.
Bronzino J. The Biomedical Engineering Handbook. 2da ed. Florida (Estados Unidos): Springer; 2000.
Gault W, Gatens P Jr. Use of low intensity direct current in management of ischemic skin ulcers. Phys Ther. 1976;56(3):265-9.
Cheng N, VanHoof H, Bock E. The effects of electric currents on ATP generation, protein synthesis, and membrane transport in rat skin. Clin Orthop Relat Res. 1982;171:264-72.
Mitchell P. Vectorial chemistry and molecular mechanism of chemiosmosis coupling: power transmission by proticity. Biochem Soc Trans. 1976;4:400-30.
Wood J, Schallreuter K, Jacobson W. A Multicenter Study on the Use of Pulsed Low-Intensity Direct Current for Healing Chronic Stage II and Stage III Decubitus Ulcers. Arch Dermatol. 1993;129(8):999-1009.
Lukaski H. Biological indexes considered in the derivation of the bioelectrical impedance analysis. J Clin Nutr. 1996;64:397S-404S.
Rosell J, Colominas J, Riu P et al. Skin Impedance From 1 to 1 MHz. Transactions on medical engineering. 1988;35:649-51.
Scott B, Flood J. Measurement of soft tissue temperature and impedance following the application of transdermal direct current. Physiotherapy. 2007;93(2):114-20.
Chumlea W, Guo S. Bioelectrical Impedance and Body Composition: Present Status and Future Directions. Nutr Rev. 1994;52(4):123-31.
Kyle U, Bosaeus I, De Lorenzo A et al. Bioelectrical impedance analysis- part I: review of principles and methods. Clin Nutr. 2004;23:1226-43.
Zhao M. Electrical fields in wound healing-An overriding signal that directs cell migration. Semin Cell Dev Biol. 2009;20(6):674-82.
Feedar J, Kloth L, Gentzkow G. Chronic dermal ulcer healing enhanced with monophasic pulsed electrical stimulation. J Phys Ther. 1991;71:639-49.
Sheridan D, Isseroff R, Nuccitelli R. Imposition of a physiologic DC electric field alters the migratory response of human keratinocytes on extracellular matrix molecules. J Invest Dermatol. 1996;106(4):642-6.
Ramtani S. Mechanical modelling of cell/ECM and cell/cell interactions during the contraction of a fibroblast-populated collagen microsphere: theory and model simulation. J Biomech. 2004;37(11):1709-18.
Nordenström B. Evidence and Necessity for Biologically Closed Electric Circuits (BCEC) in Healing, Regulation and Oncology. Integr Physiol Behav Sci. 1992;27(4):285-303.
El-Sheemy M, Muir I, Wheatley D, et al. Inhibition of the contraction of collagen gels by extracts from human dermis. Cell Biol Int. 2001;25(7):635-42.
Horch R, Kopp J, Kneser U et al. Tissue engineering of cultured skin substitutes. J Cell Mol Med. 2005;9(3):592-608.
Cameron M. Agentes Físicos en Rehabilitación: de la Investigación a la práctica. 7 Ed. Elsevier; 2009.
Watson T. Electroterapia: práctica basada en la evidencia. 12 Ed. Elsevier; 2009.
Barker A, Jaffe L, Vanable J. the glabrous epidermis of cavies contains a powerful battery. Am J Physiol. 1982;242:358-66.
Mycielska M, Djamgoz M. Cellular mechanisms of direct-current electric field effects: galvanotaxis and metastatic disease. J Cell Sci. 2004;117(9):1631-9.
Trollinger D, Isseroff R, Nuccitelli R. Calcium channels blockers inhibit galvanotaxis in human keratinocytes. J Cell Physiol. 2002;193:1-9.
Kloth L. Electrical stimulation for wound healing: a review of evidence from in vitro studies, animal experiments, and clinical trials. Int J Low Extrem Wounds. 2005;4(1):23-44.
Canaday D, Lee R. Scientific basis for clinical application of electric fields in soft tissue repair. In: Brighton C, Pollack S, Electromagnetics in biology and medicine. San Francisco: San Francisco Press; 1991.
Cooper M, Schliwa M. Electrical and ionic controls of tissue cell locomotion in DC electic fields. J Neurosci Res. 1985;13:233-44.
Orida N, Feldman J. Directional protrusive pseudopodial activity and motility in macrophages induced by extra-cellular electric fields. Cell Motil. 1982;2:243-55.
Eberhardt A, Szczypiorski P, Korytowski G. Effect of transcutaneous electrostimulation on the cell composition of skin exudate. Acta Physiol Pol. 1986;37(1):41-6.
Kloth L, Feedar J. Wound Healing: Alternatives in Management Contemporary Perspectives in Rehabilitation. Ed 2ª. Philadelphia; 1995.
Bourguignon G, Wenche J, Bourguignon L. Electric stimulation of human fibroblasts causes an increase in Ca2+ influx and the exposure of additional insulin receptors. J Cell Physiol. 1989;140(2):397-85.
Stromberg B. Effects of electrical currents on wound contraction. Ann Plast Surg. 1988;21(2):121-3.
Nishimura K, Isseroff R, Nuccitelli R. Human keratinocytes migrate to the negative pole in direct current electric fields comparable to those measured in mammalian wounds. J Cell Sci. 1996;109:199-207.
Allenby A, Fletcher J. The effect of heat, pH and organic solvents on the electrical impedance and permeability of excised human skin. Br J Dermatol. 2006;81(s4):31-9.
Balakatounis K, Angoules A. Low-intensity Electrical Stimulation in Wound Healing: Review of the Efficacy of Externally Applied Currents Resembling the Current of Injury. Journal of Plactic Surgery. 2008;8:283-91.
Feedar J, Kloth L, Gentzkow G. Monophasic Pulsed Electrical Stimulation Chronic Dermal Ulcer Healing Enhanced with. Phys Ther. 1991;71:639-49.
Brown M, Gogia P, Sinacore D et al. High-Voltage Galvanic Stimulation on Wound Healing in Guinea Pigs: Longer-Term Effects. Arch Phys Med Rehabil. 1995;76(12):1134-7.
Brown M, McDonnell M, Menton D. Polarity effects on wound healing using electric stimulation in rabbits. Arch Phys Med Rehabil. 1989;70(8):624-7.
Dunn M. Wound healing using collagen matrix: Effect of DC electrical stimulation. J Biomed Mater Res. 1988;22:191-206.
Goldman R, Pollack S. Electric fields and proliferation in a chronic wound model. Bioelectromagnetics. 1996;17(6):450-7.
Thawer H, Houghton P. Effects of electrical stimulation on the histological properties of wounds in diabetic mice. Wound Repair Regen. 2001;9(2):107-15.
Bach S, Bilgrav K, Gottrup F et al. The effect of electrical curren on skin incision. Eur J Surg. 1991;157:171-4.
Reger S, Hyodo A, Negami S, Kambic H et al. Experimental Wound healing with electrical stimulation. J Blackwell Science. 1999;23(5):460-2.
Houghton P, Kincaid C, Lovell M et al. Effect of electrical stimulation on chronic leg ulcer size and appearance. Phys Ther. 2003;83(1):17-28.
Jankovit A, Binit I. Frequency rhythmic electrical modulation system in the treatment of chronic painful leg ulcers. Arch Dermatol Res. 2008;300:377-83.
Griffin JW, Tooms RE, Mendius A et al. Efficacy of High Voltage Pulsed Current for High of Pressure Ulcers in Patients with Spinal Cord Injury. Phys Ther. 1991;71:433-44.
Godbout C, Frenette J. Periodic Direct Current Does Not Promote Wound Closure in an In Vitro Dynamic Model of Cell Migration. Phys Ther. 2006;86:50-9.
Licencia
Derechos de autor 2013 Revista de la Facultad de Medicina

Esta obra está bajo una licencia Creative Commons Reconocimiento 3.0 Unported.
-