Publicado
Mecanismos inmunológicos implicados en la patología del asma alérgica
Immunologic mechanisms involved in the pathology of allergic asthma
DOI:
https://doi.org/10.15446/revfacmed.v62n2.45417Palabras clave:
Asma, Inmunoglobulina E, Mastocitos, Eosinófilos (es)Asthma, Immunoglobulin E, Mast Cells, Eosinophils (en)
Asthma is a disease that affects people of different ages. The WHO estimates that it actually affects around 235 million people around the world, while in Colombia it estimates that is present in about 12% of the population. Asthma is characterized by an airway inflammation and a change in the structural tissue of the respiratory system as: caliciform cells epithelial hyperplasia, subepithelial collagen deposits and airway smooth muscular hypertrophy. Immunopathology of allergic asthma involves humoral and cell mediated immune response, altogether induces a state of airway hyperresponsiveness (AHR).
Inflammatory cells involved in atopic asthma are: airway epithelial cells, different sub-populations of T y B cells, mast cells, dendritic cells, eosinophils, basophils, macrophages, iNKT cells and platelets, as well as cytokines, chemokines and costimulating and regulating signals. The present paper analyses some cellular and molecular processes, considered as the most important related to the immunopathology of atopic asthma.
Referencias
Mutius E, Drazen MJ. A Patient with Asthma Seeks Medical Advice in 1828, 1928, and 2012. N Engl J Med. 2012;366:827-34.
Busse W, Lemanske RF. Asthma. N Engl J Med. 2001;344:350-62.
Crinnion WJ. Do Environmental Toxicants Contribute to Allergy and Asthma? Altern Med Rev. 2012;17:6-18.
Holgate ST. Innate and adaptive immune responses in asthma. Nat Med. 2012;18:673-83.
Grainge CL, Lau LC, Ward JA, Dulay V, Lahiff G, Wilson S, et al. Effect of Bronchoconstriction on Airway Remodeling in Asthma. N Engl J Med. 2011;364:2006-15.
Matangkasombut P, Pichavant M, De Kruyff RH, Umetsu DT. Natural killer T cells and the regulation of asthma. Mucosal Immunology. 2009;2:383-92.
Tse SM, Tantisira K, Weiss ST. The pharmacogenetics and pharmacogenomics of asthma therapy. The Pharmacogenomics Journal. 2011;11:383-92.
Dennis RJ, Caraballo L, García L, Rojas M, Rondon M, Pérez A, et al. Prevalence of asthma and other allergic conditions in Colombia 2009-2010: a cross-sectional study. BMC Pulmonary Medicine. 2012;12:17.
Fanta CH. Asthma. N Engl J Med. 2009;360:1002-14.
Kay AB. Allergy and allergic diseases. N Engl J Med. 2001;344:30-7.
Ray A, Khare A, Krishnamoorthy N, Qi Z, Ray P. Regulatory T cells in many flavors control asthma. Mucosal Immunology. 2010;3:216-29.
Langier S, Sade K, Kivity S. Regulatory T Cells in Allergic Asthma. Isr Med Assoc J. 2012;14:180-3.
Edwards MR, Bartlett NW, Hussell T, Openshaw P, Johnston SL. The microbiology of asthma. Nature Reviews Microbiology. 2012;10:459-71.
Wenzel SE. Phenotypes in asthma. Am J Respir Crit Care Med. 2004;170:579-82.
Hesselmar B, Enelund AC, Eriksson B, Padyukov L, Hanson LA, Aberg N. The heterogeneity of asthma phenotypes in children and young adults. J Allergy. 2012;2012:163089.
Barnett SB, Nurmagambetov TA. Costs of asthma in the United States: 2002-2007. J Allergy ClinImmunol. 2011;127:145-52.
Acevedo N, Sánchez J, Zakzuk J, Bornacelly A, Quiróz C, Alvarez A et al. Particular characteristics of allergic symptoms in tropical environments: follow up to 24 months in the FRAAT birth cohort study. Pulmonary Medicine. 2012;12:13.
Jeong E, Young Lee J. Intrinsic and extrinsic regulation of innate immune receptors. Yonsei Med J. 2011;52:379-92.
Kawai T, Akira S. The roles of TLRs, RLRs and NLRs in pathogen recognition. International Immunology. 2009;21:317-37.
Shi H, Kokoeva MV, Inouye K, Tzameli I, Yin H, Flier JS. TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest. 2006;116:3015-25.
Phipps S, En Lam C, Foster PS, Matthaei K. The contribution of toll-like receptors to the pathogenesis of asthma. Immunol Cell Biol. 2007;85:463-70.
Guillot L, Le Goffic R, Bloch S, Escrio N, Akira S, Chignard M, et al. Involvement of Toll-like Receptor 3 in the Immune Response of Lung Epithelial Cells to Double-stranded RNA and Influenza A Virus. J Biol Chem. 2005;280:5571-80.
Gewirtz AT, Navas TA, Lyons S, Godowski PJ, Madara JL. Cutting edge: Bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression. J Immunol. 2001;167:1882-5.
Tauro S, Yung-Chang Su, Thomas S , Schwarze J, Matthaei K, Townsend D, et al. Molecular and cellular mechanisms in the viral exacerbation of asthma. Microbes Infect. 2008;10:1014-23.
Montoya CG, Fernández MM, López MR. Reacciones y alteraciones del sistema inmune durante la infección por VIH-1. Infectio. 2006;10:250-65.
Annunziato F, Romagnani S. Heterogeneity of human effector CD4+ T cells. Arthritis Research & Therapy. 2009;11:257.
Hartenstein B, Teurich S, Hess J, Schenkel J, Kistner SM, Angel P. Th2 cell-specic cytokine expression and allergen-induced airway inflammation depend on JunB. The EMBO Journal. 2002;21: 6321-9.
Finkelman FD, Hogan SP, Hershey GK, Rothenberg ME, Wills-Karp M. Importance of Cytokines in Murine Allergic Airway Disease and Human Asthma. J Immunol. 2010;184:1663-74.
Croft M, Carter L, Swain S, Dutton R. Generation of Polarized Antigen-specific CD8 Effector Populations: Reciprocal Action of Interleukin (IL)-4 and IL-12 in Promoting Type 2 versus Type 1 Cytokine Profiles. J Exp Med. 1994;180:1715-28.
Betts RJ, Kemeny DM. CD8+ T cells in asthma: Friend or foe? Pharmacology & Therapeutics. 2009;121:123-31.
Lloyd CM, Hessel EM. Functions of T cells in asthma: more than just TH2 cells. Nat Rev Immunol. 2010;10:838-48.
Gelfand EW, Dakhama A. CD81 T lymphocytes and leukotriene B4: Novel interactions in the persistence and progression of asthma. J Allergy Clin Immunol. 2006;117:577-82.
Wills-Karp M, Luyimbazi J, Xu X, SchoFeld B, Neben TY, Karp CL, et al. Interleukin-13: Central Mediatorof Allergic Asthma. Science. 1998;282:2258.
Holgate ST. Pathogenesis of Asthma. Clinical and Experimental Allergy. 2008;38:872-97.
Besnard AG, Togbe D, Couillin I, Tan Z, Zheng SG, Erard F, et al. Inflammasome-IL-1-Th17 response in allergic lung inflammation. J Mol Cell Biol. 2012;4:3-10.
Sutton C, Brereton C, Keogh B, Mills K, Lavelle E. A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis. J Exp Med. 2006;203:1685-91.
Molet S, Hamid Q, Davoineb F, Nutku E, Tahaa R, Pagé N, et al. IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines. J Allergy Clin Immunol. 2001;108:430-8.
Souwer Y, Szegedi K, Kapsenberg ML, Jong E. IL-17 and IL-22 in atopic allergic disease. Current Opinion in Immunology. 2010;22:821-6.
Oboki K, Ohno T, Saito H, Nakae S. Th17 and Allergy. Allergology International. 2008;57:121-34.
Lloyd CM, Hawrylowicz CM. Regulatory T Cells in Asthma. Immunity. 2009;31:438-49.
Ito T, Wang YH, Duramad O, Hori T, Delespesse GJ, Watanabe N et al. TSLP-activate dendritic cells induce an inflammatory T helper type 2 cells response through OX40 ligand. J Exp Med. 2005;202:1213-23.
Hawrylowicz CM. Regulatory T cells and IL-10 in allergic inflammation. J Exp Med. 2005;202:1459-63.
Ouyang W, Rutz S, Crellin N, Valdez P, Hymowitz S. Regulation and functions of the IL-10 family of cytokines in inflammation and disease. Annu Rev Immunol. 2011;29:71-109.
Urry Z, Chambers E, Xystrakis E, Dimeloe S, Richards D, Gabrysovâ L, et al. The role of 1a,25-dihydroxyvitamin D3 and cytokines in the promotion of distinct Foxp3+ and IL-10+ CD4+ T cells. Eur J Immunol. 2012;42:2697-2708.
Stassen M, Schmitt E, Bopp T. From interleukin-9 to T helper 9 cells. Ann N Y Acad Sci. 2012;247:56-68.
Reader JR, Hyde DM, Schelegle ES, Aldrich MC, Stoddard AM, McLane MP, et al. Interleukin-9 induces mucous cell metaplasia independent of inflammation. Am J Respir Cell Mol Biol. 2003;28:664-72.
Temann UA, Geba GP, Rankin JA, Flavel RA. Expression of Interleukin 9 in the lungs of transgenic mice causes airway inflammation, mast cell hyperplasia, and bronchial hyperresponsiveness. J Exp Med. 1998;188:1307-20.
Cheng G, Arima M, Honda K, Hirata H, Eda F, Yoshida N, et al. Anti-Interleukin-9 antibody treatment inhibits airway inflammation and hyperreactivity in mouse asthma model. Am J Respir Crit Care Med. 2002;166:409-16.
Parker JM, Oh CK, Force CL, Miller SD, Pearlman DS, Le C, et al. Safety profile and clinical activity of multiple subcutaneous doses of MEDI-528, a humanized anti-interleukin-9 monoclonal antibody, in two randomized phase 2a studies in subjects with asthma. BMC Pulm Med. 2011;11:14.
Weller CL, Collington SJ, Williams T, Lamb JR. Mast cells in health and disease. Clinical Science. 2011;120:473-84.
Jonsson F, Daëron M. Mast cells and company. Front Immunol. 2012;3:16.
Supajatura V, Ushio H, Nakao A, Okumura K, Ra C, Ogawa H. Protective roles of mast cells against enterobacterial infection are mediated by Toll-Like receptor 4. J Immunol. 2001;167:2250-6.
Supajatura V, Ushio H, Nakao A, Akira S, Okumura K, Ra C, et al. Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity. J. Clin. Invest. 2002;109:1351-9.
Reuter S, Stassen M, Taube C. Mast cells in allergic asthma and beyond. Yonsei Med J. 2010;51:797-807.
Nakae S, Suto H, Iikura M, Kakurai M, Sedgwick JD, Tsai M, et al. Mast cells enhance T cell activation: importance of mast cell costimulatory molecules and secreted TNF. J Immunol. 2006;176:2238-48.
Nakae S, Suto H, Kakurai M, Sedgwick JD, Tsai M, Galli SJ. Mast cells enhance T cell activation: Importance of mast cell-derived TNF. Proc Natl Acad Sci U S A. 2005;102:6467-72.
Galli SJ, Tsai M. Mast cells: Versatile regulators of inflammation, tissue remodeling, host defense and homeostasis. J Dermatol Sci. 2008;49:7-19.
Akuthota P, Xenakis JJ, Weller PF. Eosinophils: Offenders or general bystanders in allergic airway disease and pulmonary immunity? J Innate Immun. 2011;3:113-9.
Takatsu K. Interleukin-5 and IL-5 receptor in health and diseases. Proc Jpn Acad Ser B Phys Biol Sci. 2011;87:463-85.
Mochizuki A, McEuen AR, Buckley MG, Walls AF. The release of basogranulin in response to IgE-dependent and IgE-independent stimuli: Validity of basogranulina measurement as an indicator of basophil activation. J Allergy Clin Immunol. 2003;112:102-8.
Moreira AP, Hogaboam CM. Macrophages in allergic asthma: Fine-tuning their pro- and anti-inflammatory actions for disease resolution. J Interferon Cytokine Res. 2011;31:485-91.
Varin A, Mukhopadhyay S, Herbein G, Gordon S. Alternative activation of macrophages by IL-4 impairs phagocytosis of pathogensbut potentiates microbial-induced signalling and cytokine secretion. Blood. 2010;14:115:353-62.
Zeyda M, Farmer D, Todoric J, Aszmann O, Speiser M, Gyori G, et al. Human adipose tissue macrophages are of an anti-inflammatory phenotype but capable of excessive proinflammatory mediator production. Int J Obes. 2007;31:1420-8.
Naura AS, Zerfaoui M, Kim H, Abd Elmageed ZY, Rodriguez PC, Hans CP, et al. Requirement for inducible nitric oxide synthase in chronic allergen exposure-induced pulmonary fibrosis but not inflammation. J Immunol. 2010;185:3076-85.
Iwamura C, Nakayama T. Role of NKT cells in allergic asthma. Curr Opin Immunol. 2010;22:807-13.
Lisbonne M, Diem S, Keller AC, Lefort J, Araujo LM, Hachem P, et al. Cutting Edge: Invariant Va14 NKT cells are required for allergen-induced airway inflammation and hyperreactivity in an experimental asthma model. J Inmunol. 2003;171:1637-41.
Akbari O, Faul JL, Hoyte EG, Berry GJ, Wahlstrom J, Kronenberg M, et al. CD4+ Invariant T-Cell-Receptor+ natural killer T cells in bronchial asthma. N Engl J Med. 2006;354:1117-29.
Pitchford SC, Momi S, Baglioni S, Casali L, Giannini S, Rossi R, et al. Allergen induces the migration of platelets to lung tissue in allergic asthma. Am J Respir Crit Care Med. 2008;177:604-12.
Pitchford SC, Yano H, Lever R, Riffo-Vasquez Y, Ciferri S, Rose MJ, et al. Platelets are essential for leukocyte recruitment in allergic inflammation. J Allergy Clin Immunol. 2003;112:109-18.
Pitchford SC, Riffo-Vasquez Y, Sousa A, Momi S, Gresele P, Spina D, et al. Platelets are necessary for airway wall remodeling in a murine model of chronic allergic inflammation. Blood. 2004;103:639-47.
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Derechos de autor 2014 Revista de la Facultad de Medicina
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