Correo Electrónico
DNINFOA - SIA
Bibliotecas
Convocatorias
Identidad U.N.
Publicado
Diarrea en el paciente con diabetes mellitus
Diarrhea in patients with diabetes mellitus
Palabras clave:
Diarrea, Diabetes mellitus, Complicaciones de la diabetes, Enfermedades gastrointestinales, Terapéutica (es)Diarrhea, Diabetes Mellitus, Diabetes Complications, Gastrointestinal Diseases, Therapeutics (en)
La diabetes mellitus es una enfermedad de gran prevalencia a nivel mundial que conlleva a muchas complicaciones, de las cuales las gastrointestinales son las mayormente olvidadas por el personal médico. Hasta el 22% de los pacientes con diabetes mellitus pueden tener diarrea y la causa de ello es multifactorial, pues incluye la neuropatía, efectos adversos de la terapia antidiabética, el aumento de la miocrobiota intestinal, entre otras.
El tratamiento más efectivo es el control estricto de la glucemia; sin embargo, algunos medicamentos han sido utilizados con algún tipo de beneficio en estos pacientes.
Diabetes mellitus is a highly prevalent disease worldwide leading to many complications of which gastrointestinal ones are largely neglected by physicians. Up to 22% of the patients suffering diabetes mellitus may have diarrhea, and this may be caused by multiple factors, including neuropathy, adverse effects of anti-diabetic therapy, intestinal miocrobiota increase, among other factors.
The most effective treatment against these complications consists of a strict glycemic control, however, some medicines have been used in these patients achieving some benefits for them.
Descargas
Citas
Inzucchi S. Diagnosis of Diabetes. N. Engl. J. Med. 2012;367(6):542-50. http://doi.org/8nj.
American Diabetes Association. Standards of medical care in diabetes 2015. Diabetes care. 2015;38:S5-87.
Asociación Latinoamericana de Diabetes. Guias ALAD del diagnóstico, control y tratamiento de la diabetes mellitus tipo 2. ALAD; 2013.
Organización Mundial de la Salud Media centre. Diabetes. Nueva York: OMS [updated 2012 Sep, cited 2014 Feb 13]. Available from: http://goo.gl/IMYVjS.
Feldman M, Chiller L. Disorders of Gastrointestinal Motility Associated with Diabetes Mellitus. Ann. Intern. Med. 1983;98(3):378-84. http://doi.org/8np.
Bytzer P, Talley NJ, Leemon N, Young LJ, Jones MP, Horowitz M. Prevalence of gastrointestinal symptoms associated with diabetes mellitus: a population-based survey of 15000 adults. Arch. Intern. Med. 2001;161(16):1989-96. http://doi.org/fmwtrt.
Guerrant RL, Van Gilder T, Steiner TS, Thielman NM, Slutsker L, Tauxe RV, et al. Practice guidelines for the management of infectious diarrhea. Clin. Infect. Dis. 2001;32-(3):331-51. http://doi.org/bwfqnz.
Gould M, Sellin JH. Diabetic Diarrhea. Curr. Gastroenterol. Rep. 2009;11(5):354-9. http://doi.org/dcwn7m.
Vinik AI, Erbas T. Recognizing and treating diabetic autonomic neuropathy. Cleve Clin. J. Med. 2001;68(11):928-30. http://doi.org/fxcvkk.
Camilleri M, Bharucha AE, Farrugia G. Epidemiology, mechanisms and management of diabetes gastroparesis. Clin. Gastroenterol. Hepatol. 2011;9(1):5-12. http://doi.org/fjd6dv.
Bytzer P, Talley NJ, Hammer J, Young LJ, Jones MP, Horowitz M. GI symptoms in diabetes mellitus are associated with both poor glycemic control and diabetic complications. Am. J. Gastroenterol. 2002;97(3):604-11. http://doi.org/fvj6g6.
Marulanda-Sierra VA. Manifestaciones gastrointestinales de la diabetes mellitus. Rev. Col. Gastroenterol. 2006;21(1):39-56.
Farthing MJ. The patient with refractory diarrhea. Best Pract. Res. Clin. Gastroenterol. 2007;21(3):485-501. http://doi.org/b2pnrb.
Pineda Ovalle LF, Otero W, Arbeláez V. Diarrea crónica. Diagnóstico y evaluación clínica. Rev. Col. Gastroenterol. 2004;19(2):115-26.
Gatopoulou A, Papanas N, Maltezos E. Diabetic gastrointestinal autonomic neuropathy: current status and new achievements for everyday clinical practice. Eur. J. Intern. Med. 2012;23(6):499-505. http://doi.org/8nq.
Bagyánszki M, Bodi N. Diabetes-related alterations in the enteric nervous system and its microenvironment. World J. Diabetes 2012;3(5):80-93. http://doi.org/8nr.
Chadrasekharan B, Anitha M, Blatt R, Shahnavaz N, Kooby D, Staley C, et al. Colonic motor dysfunction in human diabetes is associated with enteric neuronal loss and increased oxidative stress. Neurogastroenterol. Motil. 2011;23:131-38. http://doi.org/dbdgs6.
Franco R. Complicaciones microvasculares de la DM. Asociación Colombiana de Endocrinología. [Cited 2015 Feb 10] Available from: http://goo.gl/1Tc9h0.
Chadrasekharan B, Srinivasan S. Diabetes and the enteric nervous system. Neurogastroenterol. Motil. 2007;19(12):951-60. http://doi.org/cfjpfj.
Werth B, Meyer-Wyss B, Spinas GA, Drewe J, Beglinger C. Non-invasive assessment of gastrointestinal motility disorders in diabetic patients with and without cardiovascular signs of autonomic neuropathy. Gut. 1992;33(9):1199-203. http://doi.org/cwn9j8.
Vazeou A, Papadopoulou A, Papadimitriou A, Kitsou E, Stathatos M, Bartsocas C. Autonomic neuropathy and gastrointestinal motility disorders in children and adolescents with type 1 diabetes mellitus. J. Pediatr. Gastroenterol. Nutr. 2004;38(1):61-5. http://doi.org/fcb2x7.
Lysy J, Israeli E, Goldin E. The prevalence of chronic diarrhea among diabetic patients. Am. J. Gastroenterol. 1999;94(8):2165-70. http://doi.org/bhdhs4.
O'hara AM, SHanahan F. The gut flora as a forgotten organ. EMBO Rep. 2006;7(7):688-93. http://doi.org/c9mkr4.
Zietz B, Lock G, Straub RH, Braun B, Schölmerich J, Palitzsch K. Small-bowel bacterial overgrowth in diabetic subject is associated with cardiovascular autonomic neuropathy. Diabetes Care. 2000;23(8):1200-1. http://doi.org/b8q4hh.
Dukowicz AC, Lacy BE, Levine GM. Small intestinal bacterial overgrowth: a comprehensive review. Gastroenterol. Hepatol. 2007;3(2):112-22.
Brigid S, Steven V, James D. Gastrointestinal complications of diabetes. Endocrinol. Metab. Clin. N. Am. 2013;42(4):809-32. http://doi.org/2p7.
Vaarala O. Human intestinal microbiota and type 1 diabetes. Curr. Diab. Rep. 2013;13(5):601-7. http://doi.org/8ns.
Pernet A, Petriccioli N. Intestinal microbiota, obesity and insulin resistance. Rev. Med. Suisse. 2011;7(317):2236-8.
Virally-Monod M, Tielmans D, Kevorkian JP, Bouhnik Y, Flourie B, Porokhov B, et al. Chronic diarrhoea and diabetes mellitus: prevalence of small intestinal bacterial overgrowth. Diabetes Metab. 1998;24(6):530-6.
Holman R. Metformin as first choice in oral diabetes treatment: the UKPDS experience. Journ. Annu. Diabetol. Hotel Dieu. 2007;13-20.
Lefeber GJ, Jansen P, van Puijenbroek EP. Severe and long-lasting diarrhea not recognized as adverse effect of low dose Metformin. Eur. Geriatr. Med. 2011;2(6):373-4. http://doi.org/ctx93c.
Okayasu S, Kitaichi K, Hori A, Suwa T, Horiwaka Y, Yamamoto M, et al. The Evaluation of Risk Factors Associated with Adverse Drug Reactions by Metformin in Type 2 Diabetes Mellitus. Biol. Pharm. Bull. 2012;35(6):933-7. http://doi.org/8nt.
Bouchoucha M, Uzzan B, Cohen R. Metformin and digestive disorders. Diabetes. Metab. 2011;37(2):90-6. http://doi.org/d8zc5g.
EL-Hennawy AS, Jacob S, Mahmood AK. Metformin-Associated Lactic Acidosis Precipitated by Diarrhea. Am. J. Ther. 2007;14(4):403-5. http://doi.org/b5fh7d.
Sun F, Yu K, Yang Z, Wu S, Zhang Y, Shi L, Ji L, et al. Impact of GLP-1 receptor agonists on major gastrointestinal disorders for type 2 diabetes mellitus: a mixed treatment comparison meta-analysis. Exp. Diabetes Res. 2012;2012(1):1-14. http://doi.org/8nv.
Badiga MS, Jain NK, Casanova C, Pitchumoni CS. Diarrhea in diabectics: the role of sorbitol. J. Am. Coll. Nutr. 1990;9(6):578-82. http://doi.org/8nw.
Brelian D, Tenner S. Diarrhoea due a pancreatic disease. Best Pract. Re.s Clin. Gastroenterol. 2012;26(5):623-31. http://doi.org/f2hdz7.
Karayiannakis AJ, Bolanaki H, Kouklakis G, Dimakis K, Memet I, Simopoulos C. Ischemic colitis of the left colon in a diabetic patient. Case Rep. Gastroenterol. 2011;5(1):239-45. http://doi.org/b2rswp.
Shakov R, Salazar RS, Kagunye SK, Baddoura WJ, Debari VA. Diabetes mellitus as a risk factor for recurrence of Clostridium difficile infection in the acute care hospital setting. Am. J. Infect. Control. 2011;39(3):194-8. http://doi.org/fgpw9n.
Aktay AN, Lee PC, Kumar V, Parton E, Wyatt D, Werlin SL. The prevalence and clinical characteristics of celiac disease in juvenile diabetes in Wisconsin. J. Pediatr. Gastroenterol. Nutr. 2001;33(4):462-5. http://doi.org/dkfsd3.
Hardt PD, Hauenschild A, Nalop J, Marzeion AM, Jaeger C, Teichmann J, et al. High prevalence of exocrine pancreatic insufficiency in diabetes mellitus. A multicenter study screening fecal elastase 1 concentrations in 1.021 diabetic patients. Pancreatol. 2003;3(5):395.402. http://doi.org/b9vhvq.
Maciejewski R, Burski K, Baj J, Madej B, Burdan F, Dabrowski A, et al. Changes in pancreatic lysosomal enzymes activity as the potential factors leading to diabetic entheropathy. J. Physiol. Pharmacol. 2001;52(4):823-34.
de Kort S, Kruimel JW, Sels JP, Arts IC, Schaper NC, Masclee AA. Gastrointestinal symptoms in diabetes mellitus, and their relation to anxiety and depression. Diabetes Res. Clin. Pr. 2012;96(2):248-55. http://doi.org/f2jv38.
Fedorak RN, Field M, Chang EB. Treatment of diabetic diarrhea with clonidine. Ann. Intern. Med. 1985;102(2):197-9. http://doi.org/8nx.
Mourad FH, Gorard D, Thillainayagam AV, Colin-Jones D, Farthing MJ. Effective treatment of diabetic diarrhoea with somatostatin analogue, octreotide. Gut. 1992;33(11):1578-80. http://doi.org/dzz239.
Pimentel M. Review of rifaximine as treatment for SIBO and IBS. Expert. Opin. Investig. Drugs. 2009;18(3):349-58. http://doi.org/d885mh.
Shakil A, Church RJ, Rao SS. Gastrointestinal complications of diabetes. Am. Fam. Physician. 2008;77(12):1697-702.
Bharucha A. Fecal incontinence. Gastroenterology. 2003;124:1672-85.
Lee TH, Lee JS. Ramosetron might be useful for treating diabetic diarrhea with a rapid small bowel transit time. Korean J. Intern. Med. 2013;28(1):106-7. http://doi.org/8nz.
Sanger GJ, Alpers DH. Development of drugs for gastrointestinal motor disorders: translating science to clinical need. Neurogastroenterol. Motil. 2008;20(3):177-84. http://doi.org/cnvmdt.
Licencia
Derechos de autor 2015 Revista de la Facultad de Medicina
Esta obra está bajo una licencia Creative Commons Reconocimiento 3.0 Unported.
-
