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Anticonvulsivantes inducen síndrome de reacción a drogas con eosinofília y síntomas sistémicos (DRESS) con falla hepática fulminante
DRESS syndrome induced by anticonvulsants and fulminant hepatic failure
Palabras clave:
Anticonvulsivantes, Síndrome de hipersensibilidad a medicamentos, Ácido valproico, Fenitoína, Fallo hepático (es)Anticonvulsants, Drug Hypersensitivity Syndrome, Valproic Acid, Phenytoin, Liver Failure, Acute (en)
El síndrome de reacción a drogas con eosinofilia y síntomas sistémicos (DRESS, por sus siglas en inglés) es una reacción severa de hipersensibilidad inducida por el uso de medicamentos. Se han reportado más de 100 fármacos asociados a este síndrome y, aunque la mayoría de los pacientes tiene una evolución clínica favorable, cerca del 10% desarrolla falla orgánica múltiple e incluso culmina en la muerte. El presente artículo presenta un caso clínico de síndrome DRESS asociado a terapia anticonvulsivante que evolucionó a falla hepática fulminante; aquí se discuten la etiología, patogenia, manifestaciones clínicas, proceso diagnóstico y posible tratamiento.
The drug rash with eosinophilia and systemic symptoms syndrome (DRESS) is a severe hypersensitive reaction induced by the use of medications. More than 100 drugs associated with this syndrome have been reported and, although most patients have a favorable clinical course, about 10% develop multiple organ failure; some cases may result in the death of the patient. This paper presents a clinical case of DRESS syndrome associated with anticonvulsive therapy that evolved to fulminant hepatic failure. The etiology, pathogenesis, clinical manifestations, diagnostic process and possible treatment of this condition are addressed.
Citas
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Derechos de autor 2017 Revista de la Facultad de Medicina
Esta obra está bajo una licencia Creative Commons Reconocimiento 3.0 Unported.
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