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Secondary erythrocytosis due to hypoxemia as prognosis in exacerbated chronic pulmonary diseases
Eritrocitosis secundaria a hipoxemia como pronóstico en neumopatías crónicas exacerbadas
Palabras clave:
Polycythemia, Lung Diseases, Phlebotomy (en)Policitemia, Enfermedades pulmonares, Flebotomía (es)
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Introduction: Even though exacerbations are the main cause of emergency consultation in patients suffering from lung diseases, erythrocyte parameters are not assessed in their prognosis. Thus, determining the implications of erythrocyte parameters might contribute to define the usefulness of phlebotomy or red blood cells transfusion in these patients.
Objective: To establish a possible relationship between the different hematocrit levels with a 30-day prognosis in patients admitted with exacerbated chronic lung disease and hypoxemia.
Materials and methods: A study based on a 30-day follow-up was conducted. Variables were described using an additional categorization by hematocrit levels and an adjustment in a multivariate model through logistic regression.
Results: Follow-up was completed for 110 Patients. The frequency of anemia was 7.3% and of erythrocytosis, 14.5%. A significant association to the outcome using Anthonisen score (OR=10.45, 95%CI: 1.11-98.48, p=0.04), hypertension (OR=11.02, 95%CI: 1.32-91.75, p=0.026) and heart failure (OR=0.09, 95%CI: 0.01-0.82, p=0.032) was found.
Conclusion: This research could not determine any relationship between erythrocyte parameters and prognosis of patients suffering from pulmonary diseases; nevertheless, extreme values of hematocrits tended to have adverse outcomes.
Introducción. Aunque las exacerbaciones de las neumopatías crónicas son las principales causas de consulta a urgencias de los pacientes que las padecen, los parámetros eritrocitarios no son evaluados en su pronóstico. Por tanto, determinar las implicaciones de los parámetros eritrocitarios podría ayudar a definir la utilidad de la flebotomía o la transfusión de eritrocitos en estos pacientes.
Objetivo. Establecer si hay relación entre los distintos niveles de hematocrito con pronóstico a 30 días en pacientes con neumopatía crónica exacerbada e hipoxemia.
Materiales y métodos. Estudio de seguimiento a 30 días. Se realizó la descripción de las variables con una categorización adicional por niveles de hematocrito y un ajuste en un modelo multivariado por regresión logística.
Resultados. Se completó el seguimiento en 110 pacientes. La frecuencia de anemia fue de 7.3% y de eritrocitosis de 14.5%. Se encontró asociación significativa al desenlace con la clasificación Anthonisen (OR=10.45, IC95%: 1.11-98.48; p=0.04), hipertensión arterial (OR=11.02, IC95%: 1.32-91.75; p=0.026) y falla cardiaca (OR=0.09, IC95%: 0.01-0.82; p=0.032).
Conclusión. Este estudio no pudo determinar relación alguna entre los parámetros eritrocitarios y el pronóstico de pacientes con enfermedades pulmonares crónicas; sin embargo, hubo una tendencia a que los valores extremos del hematocrito presentaran desenlaces adversos.
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Derechos de autor 2017 Revista de la Facultad de Medicina
Esta obra está bajo una licencia Creative Commons Reconocimiento 3.0 Unported.
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