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Eritrocitosis secundaria a hipoxemia en neumopatías crónicas: de la reología a la práctica clínica
Erythrocytosis Secondary to Hypoxemia in Chronic Lung Diseases: From Rheology to Clinical Practice
Palabras clave:
Policitemia, Enfermedades pulmonares, Reología, Microcirculación, Flebotomía (es)Polycythemia, Lung Diseases, Rheology, Microcirculation, Phlebotomy (en)
La eritrocitosis es una condición infrecuente en las enfermedades pulmonares crónicas que cursan con hipoxemia; su adecuada aproximación fisiopatológica y clínica no es bien conocida. Aunque la eritrocitosis es una respuesta compensatoria frente a la hipoxemia, sus efectos en la microcirculación pueden afectar parámetros cardiovasculares con deterioro de la sintomatología de pacientes con esta patología.
La corrección por medio de la flebotomía puede ser una medida terapéutica útil, pero no hay claridad sobre su indicación en consideración a la evidencia actualmente disponible; de igual forma, existen preocupaciones sobre los desenlaces adversos que podrían generarse con su uso en la reología y en la ferrocinética. Es también desconocida la pertinencia de la flebotomía ante el aparente pronóstico benigno de quienes presentan eritrocitosis en el contexto de una neumopatía crónica.
Con la escasa información actual, se hace necesaria la ampliación de la investigación en los tópicos relacionados con la eritrocitosis debida a hipoxemia.
Erythrocytosis is a rare condition in chronic lung diseases associated to hipoxemia. It's proper clinical and pathophysiological approach is not very well known. Although erythrocytosis is a compensatory response against hypoxemia, its effects on microcirculation may affect cardiovascular parameters with symptomatic disrepair in patients with this disease.
Correction of erythrocytosis through phlebotomy may be a useful therapeutic approach, but there is no clearness about its indication considering the current evidence available; likewise, there are concerns about adverse outcomes that could be generated with its use in rheology and ferrokinetics.
It is also unknown the relevance of phlebotomy with regard to the apparent benign prognosis of patients presenting with erythrocytosis in chronic lung diseases.
With the scarce current information it is necessary to expand the research on issues related to erythrocytosis due hypoxemia.
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Derechos de autor 2016 Revista de la Facultad de Medicina
Esta obra está bajo una licencia Creative Commons Reconocimiento 3.0 Unported.
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