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Molecular mechanisms of autophagy and its role in cancer development
Mecanismos moleculares de la autofagia y su papel en el cáncer
Palabras clave:
Autophagy, Cancer, Tumorigenesis, Proliferation (en)Autofagia, Cáncer, Tumorigénesis, Proliferación (es)
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Autophagy is an evolutionary process preserved in eukaryotes, which removes harmful components and maintains cell homeostasis in response to a variety of extracellular stimuli. It is involved in both physiological and pathological conditions, including cancer.
The role of autophagy in the treatment of cancer is described as a “double-edged sword”, which reflects its involvement in tumor suppression, survival and subsequent proliferation of tumor cells. Recent advances are useful for planning appropriate adjustments to inhibit or promote autophagy in order to obtain therapeutic efficacy in cancer patients. The objectives of this review are to clarify the role of autophagy in cancer and to highlight the need for more research in the field.
La autofagia es un proceso conservado evolutivamente en eucariotas que elimina componentes dañinos y mantiene la homeostasis celular en respuesta a una serie de estímulos extracelulares. Está implicada tanto en condiciones fisiológicas como patológicas, incluyendo el cáncer.
El papel de la autofagia en el tratamiento del cáncer se describe como un “arma de doble filo”, un término que refleja su participación en la supresión tumoral, la supervivencia y la proliferación de células tumorales. Los avances recientes ayudan a proyectar los ajustes apropiados en la inhibición o la promoción de la autofagia con el objetivo de conferir eficacia terapéutica en los pacientes con cáncer. Esta revisión tiene como objetivo aclarar los roles de la autofagia en el cáncer y destacar la necesidad de una mayor investigación en el campo.Descargas
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Derechos de autor 2017 Revista de la Facultad de Medicina
Esta obra está bajo una licencia Creative Commons Reconocimiento 3.0 Unported.
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