Publicado

2019-01-01

Endotoxins and the importance of procalcitonin

Endotoxinas y la importancia de la procalcitonina

Palabras clave:

Endotoxins, Procalcitonin (en)
Endotoxinas, Procalcitonina (es)

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Autores/as

  • Paola Andrea Yasnó-Navia Universidad del Cauca - Faculty of Health Sciences - Department of Internal Medicine / Universidad del Cauca - Faculty of Health Sciences - Health Research Group (GIS)
  • Luisa Fernanda Zuñiga-Ceron Universidad del Cauca - Faculty of Health Sciences - Department of Internal Medicine / Universidad del Cauca - Faculty of Health Sciences - Health Research Group (GIS)
  • Jhan Sebastián Saavedra-Torres Universidad del Cauca - Faculty of Health Sciences - Department of Internal Medicine / Universidad del Cauca - Faculty of Health Sciences - Health Research Group (GIS)
  • María Virginia Pinzón-Fernández Universidad del Cauca - Faculty of Health Sciences - Department of Internal Medicine / Universidad del Cauca - Faculty of Health Sciences - Health Research Group (GIS)

Gram-negative bacilli and cocci bacteria produce and release endotoxins, which are lipopolysaccharides found in the outer membrane of the cell wall. These endotoxins are responsible for releasing a series of inflammatory mediators such as IL1, TNFα and proteases, as well as lipid mediators such as prostaglandins, leukotrienes, thromboxanes and platelet-activating factor, ultimately activitating immune response cells like leukocytes, macrophages and platelets. These cells amplify the response to shock, generate a procoagulant state and produce alterations at the cellular level, for example, damage to the endothelium, which in the end benefit and worsen the state of septic shock (Figure 1).

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Citas

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Licencia

Derechos de autor 2019 Revista de la Facultad de Medicina

Creative Commons License

Esta obra está bajo una licencia Creative Commons Reconocimiento 3.0 Unported.

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