Publicado

2021-01-01

Infection, treatment and virological features of SARS-CoV-2. A brief overview

Infección, tratamiento y características virológicas del SARS-CoV-2. Un breve resumen

CARACTERÍSTICAS VIROLÓGICAS, DIAGNÓSTICO E TRATAMENTO: UMA REVISÃO DA COVID-19

Palabras clave:

COVID-19, Infection, Virology, Diagnosis (en)
COVID-19, Infección, Diagnóstico, Virología (es)

Autores/as

A new coronavirus, the SARS-CoV-2, and its resulting disease, the COVID-19, originated in Wuhan, China, in December 2019, affecting human health by causing respiratory, digestive and systemic problems. In symptomatic patients, the clinical manifestations of the disease usually begin within a week after being infected with the virus, and consist of fever, dry cough, nasal congestion, fatigue and airway problems, which can lead to pneumonia. The virus is also present in patients who do not have symptoms, and therefore it is quite difficult to identify and quantify them. In this work, an overview of the virological features of SARS-CoV-2, its transmission and infection, as well as of the clinical signs and treatment of COVID-19 is carried out.

Un nuevo coronavirus, el SARS-CoV-2, y su enfermedad resultante, la COVID-19, se originó en Wuhan (China) en diciembre de 2019, afectando la salud humana al causar problemas respiratorios, digestivos y sistémicos. En los pacientes sintomáticos, las manifestaciones clínicas de la enfermedad suelen comenzar dentro de la semana siguiente a la infección por el virus y consisten en fiebre, tos seca, congestión nasal, fatiga y problemas de las vías respiratorias, que pueden provocar neumonía. El virus también está presente en pacientes asintomáticos, por lo que es bastante difícil identificarlos y cuantificarlos. En este trabajo se realiza una breve revisión de las características virológicas del SARS-CoV-2, su transmisión e infección, así como los signos clínicos y tratamiento de la COVID-19.

Um novo coronavírus, designado COVID-19, surgiu em Wuhan, China, em Dezembro de 2019, causando problemas respiratórios, digestivos e sistémicos que afectam a saúde humana. Nos doentes sintomáticos, as manifestações clínicas da doença começam geralmente dentro de uma semana, e consistem em febre, tosse, congestão nasal, fadiga e problemas das vias respiratórias, o que pode levar a pneumonia. O vírus também aparece em doentes que não apresentam sintomas, e é bastante difícil quantificá-los. Neste trabalho, foi efectuada uma revisão das características virológicas da COVID-19, tanto do seu sinal clínico, como do seu diagnóstico e tratamento.

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Pal M, Berhanu G, Desalegn C, Kandi V. Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2): An Update. Cureus. 2020;12(3):e7423. https://doi.org/ggq9zt.

Lu R, Zhao X, Li J, Niu P, Yang B, Wu H, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet. 2020;395(10224):565-74. https://doi.org/ggjr43.

Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med. 2020;382(8):727-33. https://doi.org/ggjfgx.

Liu SL, Saif L. Emerging Viruses without Borders: The Wuhan Coronavirus. Viruses. 2020;12(2):130. https://doi.org/ggn8mz.

John Hopkins University (JHU), Coronavirus Resource Center. COVID-19 Dashboard by the Center for Systems Science and Engineerins (CSSE) at Johns Hopkins University. Global Map. Baltimore, MD: JHU; 2010 [cited 2020 Oct 15]. Available from https://bit.ly/3mpu3Qz.

Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020;579(7798):270-3. https://doi.org/ggj5cg.

Rottier PJM. The Coronavirus Membrane Glycoprotein. In: Siddell SG, editor. The Coronaviridae. New York: Springer Science & Business Media; 2013 [cited 2020 Nov 30]. Available from: https://bit.ly/2UxDMIu).

Kampf G, Todt D, Pfaender S, Steinmann E. Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents. J. Hosp Infect. 2020;104(3):246-51. https://doi.org/ggm86h.

Liu DX, Liang JQ, Fung TS. Human Coronavirus-229E, -OC43, -NL63, and -HKU1. Ref. Modul. Life Sci. 2020. https://doi.org/fkq9.

Angeletti S, Benvenuto D, Bianchi M, Giovanetti M, Pascarella S, Ciccozzi M. COVID-2019: The role of the nsp2 and nsp3 in its pathogenesis. J Med Virol. 2020;92(6):584-8. https://doi.org/ggp6ch.

Peeri NC, Shrestha N, Rahman MS, Zaki R, Tan Z, Bibi S, et al. The SARS, MERS and novel coronavirus (COVID-19) epidemics, the newest and biggest global health threats: what lessons have we learned? Int J Epidemiol. 2020;49(3):717-26. https://doi.org/ggndm9.

World Health Organization (WHO). Statement on the second meeting of the International Health Regulations (2005) Emergency Committee regarding the outbreak of novel coronavirus (2019-nCoV). Geneva: WHO; 2020 [cited 2020 Jul 15]. Available from: https://bit.ly/32Vztev.

World Health Organization (WHO). WHO Director-General’s opening remarks at the media briefing on COVID-19 - 11 March 2020. Geneva: WHO; cited 2020 Jul 15]. Available from: https://bit.ly/33xCthE.

Pérez-Abreu MR, Gómez-Tejeda JJ, Dieguez-Guach RA. Características clínico-epidemiológicas de la COVID-19. Rev haban cienc méd. 2020 [cited 2020 Nov 11];19(2):e3254. Available from: https://bit.ly/2HSxIHH.

Lauer SA, Grantz KH, Bi Q, Jones FK, Zheng Q, Meredith HR, et al. The Incubation Period of Coronavirus Disease 2019 (COVID-19) From Publicly Reported Confirmed Cases: Estimation and Application. Ann Intern Med. 2020;172(9):577-82. https://doi.org/dph3.

Dexter F, Parra MC, Brown JR, Loftus RW. Perioperative COVID-19 Defense: An Evidence-Based Approach for Optimization of Infection Control and Operating Room Management. Anesth Analg. 2020;131(1):37-42. https://doi.org/ggqpgg.

Guan W, Ni Z, Hu Y, Liang W, Ou Ch, He J, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020;382(18):1708-20. https://doi.org/ggm6dh.

Geier MR, Geier DA. Respiratory conditions in coronavirus disease 2019 (COVID-19): important considerations regarding novel treatment strategies to reduce mortality. Med Hypotheses. 2020;140:109760. https://doi.org/ggtx3h.

Del Rio C, Malani PN. COVID-19-New Insights on a Rapidly Changing Epidemic. JAMA. 2020;323(14):1339-40. https://doi.org/ggpvft.

Center for disease control and Prevention (CDC). People with Certain Medical Conditions. Washington D.C.: CDC; 2020 [cited 2020 Jul 20]. Available from: https://bit.ly/3oap8DA.

Rothe C, Schunk M, Sothmann P, Bretzel G, Froeschl G, Wallrauch C, et al. Transmission of 2019-nCoV infection from an asymptomatic contact in Germany. N Engl J Med. 2020;382(10):970-1. https://doi.org/ggjvr8.

Cao Q, Chen YC, Chen CL, Chiu CH. SARS-CoV-2 infection in children: Transmission dynamics and clinical characteristics. J Formos Med Assoc. 2020;119(3):670-3. https://doi.org/ggpxkm.

Government of New South Wales (NSW). Report: COVID-19 in schools and the experience in NSW. New South Wales: NSW; 2020 [cited 2020 Jul 15]. Available from: https://bit.ly/39scAn2.

Kingdom of the Netherlands. National Institute for Public Health and the Environment Children, school and COVID-19. Ministry of Health, Welfare and Sport; 2020 [cited 2020 Jul 15]. Available from: https://bit.ly/36nUKj8.

Yeo C, Kaushal S, Yeo D. Enteric involvement of coronaviruses: is faecal-oral transmission of SARS-CoV-2 possible? Lancet Gastroenterol Hepatol. 2020;5(4): 335-7. https://doi.org/ggpx7s.

Cheng ZJ, Shan J. 2019 Novel coronavirus: where we are and what we know. Infection. 2020;48(2):155-63. https://doi.org/ggp6c8.

World Health Organization (WHO). Clinical management of COVID-19. Interim guidance. Geneve: WHO; 2020 [cited 2020 Jul 19]. Available from: https://bit.ly/3qdGyRA.

Siddiqi HK, Mehra MR. COVID-19 Illness in Native and Immunosuppressed States: A Clinical-The-rapeutic Staging Proposal. J Heart Lung Transplant. 2020;39(5):405-7. https://doi.org/fkrh.

Lai CC, Shih TP, Ko WC, Tang HJ, Hsueh PR. Severe acute respiratory síndrome coronavirus (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges. Int J Antimicrob Agents. 2020;55(3):105924. https://doi.org/ggpj9d.

Zhang H, Penninger JM, Li Y, Zhong N, Slutsky AS. Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor molecular mechanisms and potential therapeutic target. Intensive Care Med. 2020;46(4):586-90. https://doi.org/ggpx6p.

Jiang S, Shi ZL. The First Disease X is Caused by a Highly Transmissible Acute Respiratory Syn-drome Coronavirus. Virol Sin. 2020;35(3):263-5. https://doi.org/ggqj7q.