Publicado

2011-04-01

Hipercalemia: ¿Estamos usando la insulina correctamente?

Hypercalemia: ¿Are we using insulin correctly?

Palabras clave:

potasio, hipercaliemia, insulina. (es)
potassium, hyperkalemia, insulin. (en)

Descargas

Autores/as

  • Nelson L. Moreno-Ruíz DIOSALUD, Bogotá.
  • Humberto Parra Hospital Universitario de la Samaritana, Bogotá.

El potasio es el principal catión intracelular y es el determinante del potencial de reposo de la célula. Por esta razón, la hipercaliemia, frecuentemente, pero no siempre asociada a la insuficiencia renal severa, es una entidad potencialmente fatal por su capacidad para generar arritmias. En el tratamiento agudo mientras se realiza la terapia dialítica, hay varias opciones teraputicas destinadas a estabilizar la membrana y a redistribuir el potasio hacia la clula. En esta última modalidad de tratamiento se ubica la insulina que disminuye los niveles de potasio de una forma rápida aunque transitoria. No obstante, la forma de administración de la insulina varía ampliamente según escuelas de formación, la disponibilidad de recursos y el conocimiento del médico.

Potassium is the main intracellular cation and determines potential cell rest. Hypercaliemia is thus frequently, but not always, associated with severe renal failure. It is a potentially fatal entity due to its ability to produce arrhythmias. Several therapeutic options are intended to stabilize the membrane and redistribute potassium to the cell in acute treatment whilst a patient is undergoing dialysis.

Insulin is given in such treatment as it rapidly lowers potassium levels, even though such reduction is transitory. Nevertheless, insulin may be given in several ways depending on the school of formation, availability of resources and a doctor's particular knowledge.

Referencias

Acker Ch, Johnson J,Palevsky P, Greenberg A. Hyperkalemia in Hospitalized patients. Arch Intern Med. 1998; 158:917-24.

US Renal Data System. 1996 Annual data Report, Bethesda, Md. National Institute of Diabetes and Digestive and Kydney Disease. 1997; 86.

Einhorn L, Zhan M. The frequency of Hyperkalemia and its significance in chronic kidney disease. Arch Intern Med. 2009; 169:1156-62.

Guyton A. Textbook of Medical Physiology. Philadelphia. Ed. Elsevier. 2006.

Halperin M, Kamel K. Potassium. Lancet. 1998; 352: 135-40.

Ackerman Mj, Clapham DE. Ion Channels: Basic science and clinical disease. N Eng J Med. 1997; 336: 1575-86.

Féraille E, Doucet A. Sodium-Potassium-Adenosinetriphosphatase-Dependent Sodium Transport in the Kidney: Hormonal Control. Physiol Rev. 2000; 81:345-418.

Kaplan JH. Ion movements through the sodium pump. Annu Rev Physiol 47: 535-544, 1985.

DeFronzo R. The effect of insulin on renal handling of sodium, potassium, calcium and phosphate in man. J Clin Invest. 1975; 55:845-55.

Minaker K, Rowe J. Potassium homeostasis during hyperinsulinemia: effect of insulin level, â-blockade, an age. Am J Physiol. 1982; 199:373-77.

FE´ R, Rousselot M, Rajerison R, Favre H. Effect of insulin on Na1,K1-ATPase in rat collecting duct. J Physiol (Lond). 1995; 488:171-180.

Erlij D, DE Smet P, Driessche W. Insulin increases area and Na1 channel density of apical membrane of cultured kidney cells. J Physiol (Lond). 1994; 481: 533-42.

Lawrence S. Management of severe hyperkalemia. Crit Care Med. 2008; 36:3246-51.

Mount DB, Zandi-Nejad K. Hyperkalemia. In: Brenner BM (ed). The Kidney, 8th edn.Vol 1, section II,chapter 15 Philadelphia, PA: Saunders. 2007.

Mahoney BA, Smith WAD, Lo D, Tsoi K, Tonelli M, Clase C. Emergency interventions for hyperkalaemia. Cochrane Database of Systematic Reviews 2005, Issue 2. Art. No.: CD003235. DOI: 10.1002/ 14651858.CD003235.pub2.

Elliott M, Ronksley P, Clase C, Ahmed S, Hemmelgarn B. Management of patients with acute hyperkalemia. CMAJ. 2010; 182:1631-35.

Li Q, Zhou MT, Wang Y, Liu YH, Yang LQ, Zhu M, et al. Effect of insulin on hyperkalemia during anhepatic stage of liver transplantation. World J Gastroenterol. 2004;10:2427-9.

Hollander J, Calvert J. Hyperkalemia. Am Fam Physician. 2006; 73:283-90.

Lawrence S. Management of severe hyperkalemia. Crit Care Med. 2008; 36:3246-51.

Putcha N, Allon M. Management of Hyperkalemia in Dialysis Patient. Seminars in Dialysis. 2007; 20:431-39.

Blumberg A, Weidmann P, Shaw S, Gnadinger M. Effect of various therapeutic approaches on plasma potassium and major regulating factors in terminal renal failure. Am J Med. 1988; 85:507-12.

Allon M, Copkney C. Albuterol and insulin for treatment of hyperkalemia in hemodialysis patients. Kidney Int. 1990; 38:869-72.

Ngugi N, McLigeyo S, Kayima J. Treatment of hyperkalaemia by alteringThe transcellular gradient in patients with renal failure: effect of various therapeutic approaches. East Afr Med J. 1997; 73:503-9.

Allon M. Effect of bicarbonate administration on plasma potassium in dialysis patients: interactions with insulin and albuterol. Am J Kidney Dis. 1996; 28:508-14.

Kim H. Combined effects of bicarbonate and insulin with glucose in acute therapy of hyperkalemia in endstage renal disease. Nephron. 1996; 72:476-82.

Kes P. Hyperkalemia: a potentially lethal clinical condition. Acta clin Croat. 2001; 40:215-25.

Walter A, Ali A, Kurt M, Carey S. Hyperkalemia Revisited. Tex Heart Inst J 2006; 33:40-7.

Weiner D. hyperkalemia : a potential silent killer. J Am Soc Nephrol. 1998; 9:1535-43.

Guidelines for treatment of hyperkalemia in adults. Membership of the CREST Hyperkalaemia sub-group. January. 2006.

Kamel S, Wei Ch. Controversial issues in the treatment of hyperkalemia. Nephrol Dial Transplant. 2003; 18:2215-18.

Alvo M, Warnock DG. Hyperkalemia-Medical Staff Conference. West J Med. 1984; 141:666-71.

Schaefer T, Wolford R. Disorders of Potassium. Emerg Med Clin N Am. 2005; 23:723-47.

Evans K, Reddan D. Nondialytic management of Hyperkalemia and Pulmonary Edema Among End-Stage Renal Disease Patients: An Evaluation of the Evidence. Seminars in Dialysis. 2004; 17:22-29.

Manish M, Amy R. Emergency Management and Commonly Encountered Outpatient Scenarios in Patients With Hyperkalemia. Mayo Clin Proc. 2007; 82:1553-61.

Sodi-Pallares D, Testelli MR, Fishleder BL, Bisteni A, Medrano GA, Friedland C, et al. Effects of an intravenous infusion of potassium-glucose-insulin solution on electrocardiographic signs of myocardial infarction: A preliminary clinical report. Am J Cardiol. 1962; 9:166-81.

MA Mamas, L Neyses, F Fath-ordoubadi. A metaanalysis of glucose-insulin-potassium therapy for treatment of acute myocardial infarction. Exp Clin Cardiol. 2010;15:e20-e24.

Dýaz R, Goyal A, Mehta Sh, Afzal R, Xavier D. Glucose-Insulin-Potassium Therapy in Patients With ST-Segment Elevation Myocardial Infarction. JAMA. 2007; 298:2399-2405.

Ahee P, Crowe A. The management of hyperkalemia in the emergency department. J Accid Emerg Med. 2000;17:188-91.

Tran HA. Extreme hyperkalemia. South Med J. 2005; 98:729-32.

Khanna A, White WB. The management of hyperkalemia in patients with cardiovascular disease. Am J Med. 2009;122:215-21.

Visitas a la página del resumen del artículo

1241

Descargas

Los datos de descarga aún no están disponibles.

Cómo citar

Moreno-Ruíz, N. L., & Parra, H. (2011). Hipercalemia: ¿Estamos usando la insulina correctamente?. Revista De La Facultad De Medicina, 59(2), 149-154. https://revistas.unal.edu.co/index.php/revfacmed/article/view/23710