Publicado

2006-04-01

Ácidos grasos en la dieta diabetes mellitus e insulino resistencia

Unsaturated fatty acids intake and its relationship with insulin resistance in diabetes mellitus patients

Palabras clave:

diabetes mellitus, insulina, ácidos grasos trans, ácidos grasos monoinsaturados. (es)
diabetes mellitus, insulin, trans fatty acids, fatty acids, monounsaturated (en)

Descargas

Autores/as

  • Clara Eugenia Pérez G. MSc. Profesora Especial División de Lípidos y Diabetes, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá.
  • Carlos Arturo Guerrero F. MSc. PhD. Profesor Asociado, Laboratorio de Biología Molecular y Celular de virus, Unidad de Bioquímica. Facultad de Medicina, Universidad Nacional de Colombia, Bogotá.
La resistencia a la insulina es característica de la diabetes mellitus tipo 2. Como parte del tratamiento se recomienda los diabéticos, sustituir en las dietas los ácidos grasos saturados y el colesterol por ácidos grasos monoinsaturados; sin que estén del todo claro los mecanismos bioquímicos que beneficiarían a los pacientes. Es probable, entre otros mecanismos, que los ácidos grasos monoin­saturados aumenten la sensibilidad a la insulina. Esta revisión analiza la relación entre el tipo de ácido graso en la dieta y la resistencia a insulina en la diabetes mellitus tipo 2.
One of the most important characteristic in the obese patient with diabetes mellitus type 2 is the noticeable insulin resistance. Physicians recommended to these patients replace saturated fatty acids and cholesterol by greater dietary monounsaturated fatty acids content, without being absolutely sure about the biochemical mechanisms by which, this change, might help then. It is possible that monounsaturated fatty acids increase sensitivity to the insulin within another mechanism. The following revision is focused in the relationship between the type of dietary fatty acids ingestion and the resistance to insulin in diabetes mellitus type 2 patients.

Referencias

Ginsberg BH, Chaterjee P, Yorek M. Increased membrane fluidity is associated with greater sensitivity to insulin. Diabetes. 1987;36 supl 1:51A. abstract.

Ginberg BH, Jabour J, Spector AA. Effect of alterations in membrane lipid unsaturation on the properties of the insulin receptor of Ehrlich ascites cells. Biochim Biophys Acta. 1982;690:157-164.

Storlien LH, Jenkins AB, Chisholm DJ, Pascoe WS, Khouri S and Kraegn EW. Influence of dietary fat composition on development of insulin resistence in rats. Relationship to muscle triglyceride and omega-3 fatty acids in muscle phospholipid. Diabetes. 1991;40:280-289.

Borkman M, Storlien LH, Pan DA, Jenkins AB, Chisholm DJ. The relation between insulin sensitivity and the fatty acid composition of skeletal muscle phospholipids. N Eng J Med 1993;328:238-244.

Anderson A, Nälsen C, Tengblad S. Fatty acid composition of skeletal muscle reflects dietary fat composition in humans. Am J Clin Nutr. 2002;76:1222-1229.

Stein DT, Esser V, Stevenson B, Lane K. Essentiality of circulating fatty acids for glucose stimulated insulin secretion in the fasted rat. J. Clin. Inv. 1996;97:2728-2735.

Stein DT, Stevenson BE, Chester MW, Basit M, Daniels MB, Turley SD. The insulinotropic potency of fatty acids is influenced profoundly by their chain length and degree of saturation. J. Clin. Inv. 1997;100:398-403.

Dobbins RL, Szczepaniak LS, Myhill J, Tamura Y, Uchino H, Giacca A. The composition of dietary fat directly influences glucose stimulated insulin secretion in rat. Diabetes. 2002;51:1825-1833.

Usui I, Takata Y, Imamura T, Morioka H, Sasaoka T, Sawa T, Ishihara H. Fatty acid induced insulin resistence in rat-1 fibroblasts overexpressing human insulin receptors: impaired insulin stimulated mitogen activatyed protein kinase activity. Diabetologia. 1997;40:894-901.

Rocca AS, lagreca J, Kalitsky J, Brubaker PL. Monounsaturated fatty acid diets inprove glycemic tolerance through increased secretion of glucagon like peptide-1. Endocrinology. 2001;142:1148-1155.

Storlien LH, Baur LA, Kriketos AD. Dietary fat and insulin action. Diabetologia. 1996;39:621-631.

Vessby B, Tengblad S, Lithell H. The insulin sensitivity is related to the fatty acids of the serum lipids and of the skeletal muscle phospholipids in 70 year old men. Diabetologia. 1994:37:1044-1050.

Pan DA, Lillioja S, Milner MR. Skeletal muscle membrane lipid composition is related to adiposity and insulin accion. J Clin Invest. 1995;96:2802-2808.

Vessby B, Uusitupa M, Hermansen K, riccardi G, Rivellese AA. Substituting dietary saturated for monounsaturated fat impairs insulin sensitivity in healthy men and women: the KANWU stydy. Diabetologia. 2001;44:312-319.

The American Diabetes Association: Nutrition recommendations and principles for people with diabetes mellitus (position Statement). Diabetes Care. 1994;17:519-522.

Louherant AM, Sarkkinen ES, Vidgren HM, Schwab US, Uusitupa MI. Association of the fatty acid profile of serum lipids with glucose and insulin metabolism during 2 fat modified diets in sujects with impaired glucose tolerance. Am. J. Clin. Nutr. 2002;76:331-337.

Meyer KA, Kushi LH, Jacobs SR, Folsom AR. Dietary fat and incidence of tipe 2 diabetes in older Iowa women. Diabetes care. 2001;24:1528-1535.

Woodman RJ, Mori TA, Burke V. Effects of purified eicosapentaenoic and docosahexaenoic acid on glycemic control, blood pressure, and serum lipid in type 2 diabetic patients with treated hypertension. Am. J. Clin. Nutr. 2002;76:1007-1015.

Lundgren H, Bengtsson C, Blohme G, Isaksson B. Dietary habits and incidence of noninsulin-dependent diabetes mellitus in a population study of women in Gothenburg Sweden. Am J Clin. Nut. 1989;49:708-712.

Medalie JH, Papier C, Herman JB, Goldbourt U. Diabetes mellitus among 10.000 adult men. I. Five-year incidence and associated variables. Isr. J. Med. Sci. 1974;10:681-697.

Pelikanova T, Kohout M, Valek J, Base J, Kazdova L. Insulin secretion and insulin action related to the serum phospholipid fatty acid pattern in healthy men. Metabolism. 1989;38:188-192.

Boden G. Fatty acid and insulin resistence. Diabetes Care. 1996;19:394-395.

Visitas a la página del resumen del artículo

1133

Descargas

Los datos de descarga aún no están disponibles.

Cómo citar

Ácidos grasos en la dieta diabetes mellitus e insulino resistencia. (2006). Revista De La Facultad De Medicina, 54(2), 134-142. https://revistas.unal.edu.co/index.php/revfacmed/article/view/43852

Licencia

Derechos de autor 2006 Revista de la Facultad de Medicina

Creative Commons License

Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.

-