Publicado

2016-10-01

Prevalencia de hipotiroidismo en una población dislipidémica mayor de 35 años de Manizales, Colombia

Prevalence of hypothyroidism in a dyslipidemic population over age 35 in Manizales, Colombia

Palabras clave:

Hipotiroidismo, Lípidos, Metabolismo (es)
Hypothyroidism, Lipids, Metabolism (en)

Descargas

Autores/as

  • José Henry Osorio Universidad de Caldas - Facultad de Ciencias para la Salud - Departamento de Ciencias Básicas de la Salud - Laboratorio de Investigación en Bioquímica Clínica y Patología Molecular - Manizales - Colombia. Universidad de Manizales - Laboratorio de Investigación en Metabolismo - Manizales - Colombia.
  • César Augusto Aguirre Universidad de Manizales - Laboratorio de Investigación en Metabolismo - Manizales - Colombia.

Introducción. La hormona estimulante de la tiroides (TSH por Thyroid-Stimulating Hormone) actúa como reguladora de lípidos en el metabolismo y puede incidir en el desarrollo de enfermedades cardiovasculares y dislipidemias.

Objetivo. Determinar la prevalencia de hipotiroidismo en pacientes mayores de 35 años diagnosticados con alguna dislipidemia, con o sin tratamiento farmacológico.

Materiales y métodos. Se realizó un estudio transversal que analizó el perfil lipídico y tiroideo de 206 pacientes que presentaron alguna dislipidemia entre el 15 de enero y el 15 de junio de 2013 en una IPS de Manizales; esto, con previo consentimiento informado y diligenciamiento de encuesta.

Resultados. El 81.1% de los participantes presentaron hipercolesterolemia no controlada según referencia comercial y 49% se consideraron hipercolesterolémicos para el valor de referencia ATPIII. 2 de los participantes (0.97%) presentaron hipotiroidismo clínico por sus niveles bajos de T4L y 8 (3.9%), hipotiroidismo subclínico debido a que manifestaron niveles de TSH superiores a 6.16 μUI/ml.

Conclusiones. Se recomienda la valoración de los niveles de TSH en hombres y mujeres mayores de 35 años con alteraciones en el metabolismo de lípidos.

Introduction: The thyroid hormone acts as a regulator of lipids in metabolism and can affect the development of cardiovascular diseases and dyslipidemia.

Objective: To determine the prevalence of hypothyroidism in patients older than 35 years, diagnosed with some dyslipidemia, with or without pharmacotherapy.

Materials and methods: Cross-sectional study in which the lipid and thyroid profile of 206 patients, with some type of dyslipidemia, in a health delivery center of Manizales, was analyzed between January 15 and June 15, 2013; prior informed consent and completion of a survey were requested.

Results: 81.1% of participants had hypercholesterolemia that was not controlled with a commercial reference and 49% were considered hypercholesterolemic in relation to the ATP III reference value. Two participants (0.97%) had clinical hypothyroidism caused by low levels of FT4 and 8 (3.9%) had subclinical hypothyroidism due to TSH levels greater than 6.16 μIU/ml.

Conclusions: The valuation of TSH levels in men and women over 35, with alterations in lipid metabolism, is recommended.

Descargas

Los datos de descargas todavía no están disponibles.

Citas

Klein I, Ojamaa K. Thyroid hormone and the cardiovascular system. Curr. Opin. Endocrinol. Diabetes Obes. 1997;4(5):341-6. http://doi.org/fvpnc6.

Biondi B, Palmieri EA, Lombardi G, Fazio S. Effects of subclinical thyroid dysfunction on the heart. Ann. Intern. Med. 2002;137(11):904- 14. http://doi.org/bt78.

Biondi B. Cardiovascular effects of mild hypothyroidism. Thyroid. 2007;17(7):625-30. http://doi.org/dbchrd.

Feldt-Rasmussen U. Is the treatment of subclinical hypothyroidism beneficial? Nat. Rev. Endocrinol. 2009;5(2):86-7. http://doi.org/d3522x.

Reaven GM. Role of insulin resistance in human disease. Diabetes. 1988;37(12):1595-607. http://doi.org/bm28.

Mykkänen L, Haffner SM, Rönnemaa T, Bergman RN, Laakso M. Low insulin sensitivity is associated with clustering of cardiovascular disease risk factors. Am. J. Epidemiol. 1997;146(4):315-21. http://doi.org/bvdd.

Genest J Jr, Cohn JS. Clustering of cardiovascular risk factors: targeting high- risk individuals. Am. J. Cardiol. 1995;76(2):8A-20A. http://doi.org/bs2bdv.

Pallas D, Koutras DA, Adamopoulos P, Marafelia P, Souvatzoglou A, Piperingos G, et al. Increased mean serum thyrotropin in apparently euthyroidhypercholesterolemic patients: does it mean occult hypothyroidism? J. Endocrinol. Invest. 1991;14(9):743-6. http://doi.org/bvdf.

Bakker SJ, ter Maaten JC, Popp-Snijders C, Slaets JP, Heine RJ, Gans RO. The relationship between thyrotropin and low density lipoprotein cholesterol is modified by insulin sensitivity in healthy euthyroid subjects. J. Clin. Endocrinol. Metab. 2001;86(3):1206-11. http://doi.org/bvdg.

Michalopoulou G, Alevizaki M, Piperingos G, Mitsibounas D, Mantzos E, Adamopoulos P, et al. High serum cholesterol levels in persons with “high- normal” TSH levels: should one extend the definition of subclinical hypothyroidism? Eur. J. Endocrinol. 1998;138(2):141-5. http://doi.org/fqqcf7.

Ayala A, Danese M, Ladenson P. When to treat mild hypothyroidism. Endocrinol. Metabol. Clin. North Am. 2000;29(2):399-415. http://doi.org/cwcq9t.

Paoli-Valeri M, Mamán-Alvarado D, Jiménez-López V, Arias-Ferreira A, Bianchi G, Arata-Bellabarba G. Frecuencia de hipotiroidismo subclínico en niños sanos y con alteraciones neurológias en el estado Mérida-Venezuela. Invest. Clín. 2003;44(3):209-18.

Karlin NJ, Weintraub N, Chopra IJ. Current controversies in endocrinology: screening of asymptomatic elderly for subclinical hypothyroidism. J. Am. Med. Dir. Assoc. 2004;5(5):333-6. http://doi.org/dtpwdh.

Díez JJ, Iglesias P, Burman KD. Spontaneous normalization of thyrotropin concentrations in patients with subclinical hypothyroidism. J. Clin. Endocrinol. Metab. 2005;90(7):4124-7. http://doi.org/b632v4.

Chubb SAP, Davis WA, Davis TME. Interactions among thyroid function, insulin sensitivity, and serum lipid concentrations: the Fremantle diabetes study. J. Clin. Endocrinol. Metab. 2005;90(9):5317-20. http://doi.org/dn3cm2.

Strollo F, Carucci I, Morè M, Marico G, Strollo G, Masini MA, et al. Free triiodothyronine and cholesterol levels in euthyroid elderly T2DM patients. Int. J. Endocrinol. 2012;2012:1-7. http://doi.org/bvhb.

Celi FS, Zemskova M, Linderman JD, Smith S, Drinkard B, Sachdev V, et al. Metabolic effects of Liothyronine Therapy in hypothyroidism: a randomized, double-blind, crossover trial of Liothyronine versus Levothyroxine. J. Clin. Endocrinol. Metab. 2011;96(11):3466-74. http://doi.org/bmp48h.

Barbagallo CM, Averna MR, Liotta A, La Grutta S, Maggio C, Casimiro L, et al. Plasma levels of lipoproteins and apolipoproteins in congenital hypothyroidism: effects of l-thyroxine substitution therapy. Metabolism. 1995;44(10):1283-7. http://doi.org/ffd294.

Tagami T, Madison LD, Nagaya T, Jameson JL. Nuclear receptor corepressors activate rather than suppress basal transcription of genes that are negatively regulated by thyroid hormone. Mol. Cell. Biol. 1997;17(5):2642-8.http://doi.org/bvdh.

Tong PC, Kong AP, So WY, Yang X, Ho CS, Ma RC, et al. The usefulness of the International Diabetes Federation and the National Cholesterol Education Program’s Adult Treatment Panel III definitions of the metabolic syndrome in predicting coronary heart disease in subjects with type 2 diabetes. Diabetes Care. 2007;30(5):1206-11.http://doi.org/c985s4.

Risal P, Maharjan BR, Koju R, Makaju RK, Gautam M. Variation of total serum cholesterol among the patient with thyroid dysfunction. Kathmandu Univ. Med. J. 2010;8(30):265-8.http://doi.org/c7g9qp.

Gnoni GV, Rochira A, Leone A, Damiano F, Marsigliante S, Siculella L. 3,5,3’triiodo-L-thyronine induces SREBP-1 expression by non-genomic actions in human HEP G2 cells. J. Cell. Physiol. 2012;227(6):2388- 97. http://doi.org/dwbhhn.

Lopez D, Abisambra-Socarrás JF, Bedi M, Ness GC. Activation of the hepatic LDL receptor promoter by thyroid hormone. Biochim. Biophys. Acta. 2007;1771(9):1216-25. http://doi.org/c8sggj.

Walton KW, Scott PJ, Dykes PW, Davies JW. The significance of alterations in serum lipids in thyroid dysfunction. II. Alterations of the metabolism and turnover of 131-I-low-density lipoproteins in hypothyroidism and thyrotoxicosis. Clin. Sci. 1965;29(2):217-38.

Kumar HK, Yadav RK, Prajapati J, Reddy CV, Raghunath M, Modi KD. Association between thyroid hormones, insulin resistance, and metabolic syndrome. Saudi Med. J. 2009;30(7):907-11.

Taneichi H, Sasai T, Ohara M, Honma H, Nagasawa K, Takahashi T, et al. Higher serum free triiodothyronine levels within the normal range are associated with metabolic syndrome components in type 2 diabetic subjects with euthyroidism. Tohoku J. Exp. Med. 2011;224(3):173-8. http://doi.org/bkbp4b.

Kadiyala R, Peter R, Okosieme OE. Thyroid dysfunction in patients with diabetes: clinical implications and screening strategies. Int. J. Clin. Pract. 2010;64(8):1130-9. http://doi.org/dcd765.

Iizuka K, Takeda J, Horikawa Y. Glucose induces FGF21 mRNA expression through ChREBP activation in rat hepatocytes. FEBS Lett. 2009;583(17):2882-6. http://doi.org/fgbgr3.

Ortiz-Pérez L, de la Espriella M. Thyroid hormones and mood disorders. Rev. Colomb. Psiquiatr. 2004;33(1):98-107.

Attia J, Margetts P, Guyatt G. Diagnosis of thyroid disease in hospitalized patients: a systematic review. Arch. Intern. Med. 1999;159(7):658-65. http://doi.org/fk6pjh.

Cooper DS. Subclinical hypothyroidism. N. Eng. J. Med. 2001;345(4):260- 5. http://doi.org/cgk8qc.

Papaleontiou M, Haymart MR. Approach to and treatment of thyroid disorders in the elderly. Med. Clin. North Am. 2012;96(2):297-310. http://doi.org/bvdj.

Mooradian AD. Subclinical hypothyroidism in the elderly: to treat or not to treat? Am. J. Ther. 2011;18(6):477-86. http://doi.org/bqkcz6.

Hernández A, López LE, Hernández A, Mesa A. Hipotiroidismo subclínico en el anciano ambulatorio. Rev. Biomed. 2007;18(3):162-6. 35. Medicina Interna de Galicia. Lugo: Sociedad Gallega de Medicina interna; 2016 [cited 2016 Dic 6]. De Suárez B. Hipotiroidismo subclínico: ¿controversia o consenso? Available from: http://goo.gl/HzkXH0.

Medicina Interna de Galicia. Lugo: Sociedad Gallega de Medicina in-terna; 2016 [cited 2016 Dic 6]. De Suárez B. Hipotiroidismo subclínico: ¿controversia o consenso? Available from: http://goo.gl/HzkXH0