Use of systemic lidocaine for postoperative acute pain management in single-lung transplantation: Case report
Lidocaína sistémica para el tratamiento del dolor agudo posoperatorio en trasplante unipulmonar. Reporte de caso
Palabras clave:
Acute Pain, Lung, Transplantation, Lidocaine, Metabolism (en)Dolor agudo, Pulmón, Trasplante, Lidocaína, Metabolismo (es)
Descargas
Introduction: Lung transplantation is associated with severe pain, which can delay recovery. Systemic lidocaine has useful analgesic properties for managing acute pain; however, little is known on its use after lung transplantation. Due to pharmacological alterations during the postoperative period, the use of analgesics implies a demanding process to avoid toxicity, so lidocaine may play a role in this scenario. In this sense, the purpose of this case report is to present the use of systemic lidocaine as an option for acute pain management when other analgesics fail.
Case presentation: The following is the case of a male patient with acute pain in the postoperative period of single-lung transplantation. Opioids and non-opioid analgesics showed limited efficacy, so systematic lidocaine was administered. Systemic administration of lidocaine was effective for pain control, functional recovery, and opioid decrease during the postoperative period.
Conclusions: Systemic administration of lidocaine was a useful alternative for achieving optimal postoperative pain management in lung transplantation, since it allowed adequate analgesia and lung function recovery with decreased use of opioids. This drug may be a component of multimodal analgesia in selected patients when other options fail however, its routine use is not recommended.
Introducción. El trasplante pulmonar se asocia con dolor severo, lo que puede retrasar la recuperación del paciente. La lidocaína sistémica tiene propiedades analgésicas útiles para el manejo del dolor agudo; sin embargo, su uso después del trasplante pulmonar es poco conocido. Debido a las alteraciones farmacológicas durante el período posoperatorio, el uso de analgésicos es un proceso exigente para evitar toxicidad, por lo que la lidocaína puede tener un rol en ese contexto. En este sentido, el objetivo del presente reporte es describir el uso de lidocaína sistémica como una opción para el manejo del dolor cuando otros analgésicos han fallado.
Presentación del caso. Paciente masculino con dolor severo en el posoperatorio de un trasplante unipulmonar. El uso de opioides y de analgésicos no opioides mostró una eficacia limitada, por lo que se decidió aplicar lidocaína sistémica, la cual fue efectiva para el control del dolor, la recuperación funcional y la disminución de opioides durante el período posoperatorio.
Conclusiones. La lidocaína sistémica fue un fármaco útil para el manejo del dolor posoperatorio del trasplante de pulmón, ya que permitió una analgesia adecuada y una recuperación funcional pulmonar con menor uso de opioides. Este fármaco puede ser parte de la analgesia multimodal en pacientes seleccionados cuando otras opciones analgésicas han fallado; sin embargo, no se recomienda su uso rutinario.
Descargas
Citas
Sgalla G, Biffi A, Richeldi L. Idiopathic pulmonary fibrosis: Diagnosis, epidemiology and natural history. Radiology. 2016;21(3):427-37. http://doi.org/f8fzdg.
Gottlieb J. Lung trasplantation for interstitial lung diseases. Curr Opin Pulm Med. 2014;20(5):457-62. http://doi.org/f6c7kc.
Mesbah A, Yeung J, Gao F. Pain after thoracotomy. BJA Education. 2016;16(1):1-7. http://doi.org/dsvd.
Beloeil H, Sulpice L. Peri-operative pain and its consequences. J Visc Surg. 2016;153(6S):S15-8. http://doi.org/f9dmkj.
De Cosmo G, Aceto P, Gualtieri E, Congedo E. Analgesia in thoracic surgery: review. Minerva Anestesiol. 2009;75(6):393-400.
Katz J, Jackson M, Kavanagh BP, Sandler AN. Acute pain after thoracic surgery predicts long-term post-thoracotomy pain. Clin J Pain. 1996;12(1):50-5. http://doi.org/csg7wm.
Blichfeldt-Eckhardt MR, Andersen C, Ørding H, Licht PB, Toft P. From acute to chronic pain after thoracic surgery: the significance of different components of the acute pain response. J Pain Res. 2018;11:1541-8. http://doi.org/dsvf.
Wildgaard K, Ravn J, Kehlet H. Chronic post-thoracotomy pain: a critical review of pathogenic mechanisms and strategies for prevention. Eur J Cardiothorac Surg. 2009;36(1):170-180. http://doi.org/dfbvbj.
Richard C, Girard F, Ferraro P, Chouinard P, Boudreault D, Ruel M, et al. Acute postoperative pain in lung transplant recipients. Ann Thorac Surg. 2004;77(6):1951-5. http://doi.org/dn4t2d.
Kranke P, Jokinen J, Pace NL, Schnabel A, Holman MW, Hahnenkamp K, et al. Continuous intravenous perioperative lidocaine infusion for postoperative pain and recovery. Cochrane Database Syst Rev. 2015;(7):CD009642. http://doi.org/f7qrxs.
Alzahrani T. Pain relief following thoracic surgical procedures : A Literature Review of the Uncommon Techniques. 2017;11(3):327-331. http://doi.org/gbp4ts.
Gritsenko K, Khelemsky Y, Kaye AD, Vadivelu N, Urman RD. Multimodal therapy in perioperative analgesia. Best Pract Res Clin Anaesthesiol. 2014;28(1):59-79. http://doi.org/dsvh.
Matute-Crespo M, Montero-Matamala A. Avances farmacológicos en el manejo multimodal de la analgesia perioperatoria. Rev Esp Anestesiol Reanim. 2017;64(8):467-71. http://doi.org/dsvj.
Chou R, Gordon DB, de Leon-Casasola OA, Rosenberg JM, Bickler S, Brennan T, et al. Management of Postoperative Pain: A Clinical Practice Guideline From the American Pain Society, the American Society of Regional Anesthesia and Pain Medicine, and the American Society of Anesthesiologists’ Committee on Regional Anesthesia, Executive Committee, and Administrative Council. J Pain. 2016;17(2):131-57. http://doi.org/f786f5.
Wick EC, Grant MC, Wu CL. Postoperative multimodal analgesia pain management with nonopioid analgesics and techniques: a review. JAMA Surg. 2017;152(7):691-7. http://doi.org/gbpv59.
Weibel S, Jokinen J, Pace NL, Schnabel A, Hollmann MW, Hahnenkamp K, et al. Efficacy and safety of intravenous lidocaine for postoperative analgesia and recovery after surgery: a systematic review with trial sequential analysis. Br J Anaesth. 2016;116(6):770-83. http://doi.org/f8mj63.
Cooke C, Kennedy ED, Foo I, Nimmo S, Speake D, Paterson HM, et al. Meta-analysis of the effect of perioperative intravenous lidocaine on return of gastrointestinal function after colorectal surgery. Tech Coloproctol. 2019;23(1):15-24. http://doi.org/dsvk.
Dunn LK, Durieux ME. Perioperative Use of Intravenous Lidocaine. Anesthesiology. 2017;126(4):729-37. http://doi.org/dsvm.
de Oliveira CMB, Issy AM, Sakata RK. Intraoperative Intravenous Lidocaine. Rev Bras Anesthesiol. 2010;60(3):325-33. http://doi.org/f2qjv4.
Weinberg L, Peake B, Tan C, Nikfarjam M. Pharmacokinetics and pharmacodynamics of lignocaine: A review. World J Anesthesiol. 2015;4(2):17-29. http://doi.org/ggfwc9.
Eipe N, Gupta S, Penning J. Intravenous lidocaine for acute pain: an evidence-based clinical update. BJA Education. 2016;16(9):292-8. http://doi.org/dsvn.
Bill TJ, Clayman MA, Morgan RF, Gampper TJ. Lidocaine Metabolism: Pathophysiology, Drug Interactions, and Surgical Implications. Aesthetic Surg J. 2004;24(4):307-11. http://doi.org/ft3r33.
Aoki M, Okudaira K, Haga M, Nishigaki R, Hayashi M. Contribution of Rat Pulmonary Metabolism to the Elimination of Lidocaine, Midazolam, and Nifedipine. Drug Metab Dispos. 2010;38(7):1183-8. http://doi.org/bnbctj.
Rogliani P, Calzetta L, Rendina EA, Massullo D, Dauri M, Rinaldi B, et al. The influence of propofol, remifentanil and lidocaine on the tone of human bronchial smooth muscle. Pulm Pharmacol Ther. 2013;26(3):325-31. http://doi.org/dsvq.
Serra MF, Anjos-Valotta EA, Olsen PC, Couto GC, Jurgilas PB, Cotias AC, et al. Nebulized lidocaine prevents airway inflammation, peribronchial fibrosis, and mucus production in a murine model of asthma. Anesthesiology. 2012;117(3):580-91. http://doi.org/f37qg7.
Schmid RA, Yamashita M, Ando K, Tanaka Y, Cooper JD, Patterson GA. Lidocaine reduces reperfusion injury and neutrophil migration in canine lung allografts. Ann Thorac Surg. 1996;61(3):949-55. http://doi.org/bxcmjb.
Garutti I, Rancan L, Simón C, Cusati G, Sanchez-Pedrosa G, Moraga F, et al. Intravenous lidocaine decreases tumor necrosis factor alpha expression both locally and systemically in pigs undergoing lung resection surgery. Anesth Analg. 2014;119(4):815-28. http://doi.org/f6g99s.
Licencia
Derechos de autor 2020 Revista de la Facultad de Medicina

Esta obra está bajo una licencia Creative Commons Reconocimiento 3.0 Unported.
-