Publicado

2008-07-01

Uso de antibióticos en endoftalmitis infecciosa

Antibiotics use in infectious endophthalmitis

Palabras clave:

endoftalmitis, epidemiología, microbiología, prevención y control, terapia. (es)
endophthalmitis, epidemiology, microbiology, prevention and control, therapy. (en)

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Autores/as

  • Jorge Alberto Cortés Departamento de Medicina y Grupo de Investigación en Enfermedades Infecciosas, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá Correspondencia:
  • Carlos Fernando Cortés-Luna Clínica de Ojos, Bogotá, Colombia
La endoftalmitis bacteriana es una complicación infrecuente pero con desenlaces adversos desde el punto de vista de morbilidad y resultado funcional visual. Se discute la penetración de los antimicrobianos a las cámaras intraoculares y sus posibles implicaciones clínicas. Se presentan los factores de riesgo para endoftalmitis post-operatoria, post-traumática y endógena, y el papel que juegan los antimicrobianos en los diferentes escenarios clínicos para la prevención y el manejo de estas entidades.
Bacterial endophthalmitis is an uncommon but serious complication with unfortunate outcomes in terms of morbidity and visual function. In the present review, penetration of antimicrobials to intraocular chambers is shown with the possible clinical implications.
Risk factors for exogenous and endogenous endophthalmitis are reviewed as well as the roll for antimicrobials in each condition.

Referencias

Fahmy JA. Endophthalmitis following cataract extraction: a study of 24 cases in 4,498 operations. Acta Ophthalmol Scand. 1975; 53:522-536.

Schmitz S, Dick HB, Krummenauer F, Pfeiffer N. Endophthalmitis in cataract surgery: results of a German survey. Ophthalmology. 1999;106:1869-1877.

Fisch A, Salvanet A, Prazuck T, Forestier F, Gerbaud L, Coscas G, et al. Epidemiology of infective endophthalmitis in France: the French Collaborative Study Group on Endophthalmitis. Lancet. 1991;338:1373-1376.

Goldblum D, Rohrer K, Frueh BE, Theurillat R,Thormann W, Zimmerli S. Ocular distribution of intravenously administered lipid formulations of amphotericin B in a rabbit model. Antimicrob Agents Chemother. 2002; 46: 3719-23.

Voutsinas P, Kavouklis E, Voutsinas D, Kontoghiorgi K, Giamarellou H. The effect of acetazolamide on the kinetics of four newer beta-lactams in the aqueous humor. Clin Microbiol Infect. 2001; 7: 70-4.

Jay WM, Aziz MZ, Rissing JP, Shockley RK. Pharmacokinetic analysis of intravitreal ceftriaxone in monkeys. Arch Ophthalmol. 1985; 103: 121-3.

Hui M, Kwok AK, Pang CP, Cheung SW, Chan RC, Lam DS, et al. An in vitro study on the compatibility and precipitation of a combination of ciprofloxacin and vancomycin in human vitreous. Br J Ophthalmol 2004; 88: 218-22.

Ghazi-Nouri SM, Lochhead J, Mearza AA, Qureshi MA, Thompson GM, Cowdrey G, et al. Penetration of oral and topical ciprofloxacin into the aqueous humour. Clin Experiment Ophthalmol 2003; 31: 40-3.

García-Sáenz MC, Arias-Puente A, Fresnadillo-Martinez MJ, Carrasco-Font C. Human aqueous humor levels of oral ciprofloxacin, levofloxacin, and moxifloxacin. J Cataract Refract Surg 2001; 27: 1969-74.

Sakamoto H, Sakamoto M, Hata Y, Kubota T, Ishibashi T. Aqueous and vitreous penetration of levofloxacin after topical and/or oral administration. Eur J Ophthalmol 2007; 17: 372-6.

Costello P, Bakri SJ, Beer PM, Singh RJ, Falk NS , Peters GB, Melendez JA. Vitreous penetration of topical moxifloxacin and gatifloxacin in humans. Retina. 2006; 26: 191-5.

Hariprasad SM, Mieler WF, Holz ER. Vitreous and aqueous penetration of orally administered gatifloxacin in humans. Arch Ophthalmol 2003; 121: 345-50.

Haider SA, Hassett P, Bron AJ. Intraocular vancomycin levels after intravitreal injection in post cataract extraction endophthalmitis. Retina. 2001; 21: 210-3.

Souli M, Kopsinis G, Kavouklis E, Gabriel L, Giamarellou H. Vancomycin levels in human aqueous humour after intravenous and subconjunctival administration. Int J Antimicrob Agents 2001; 18: 239-43.

Fiscella RG, Lai WW, Buerk B, Khan M, Rodvold KA, Pulido JS, Labib S, Shapiro MJ, Blair NP. Aqueous and vitreous penetration of linezolid (Zyvox) after oral administration. Ophthalmology. 2004;111:1191-5.

Campochiano PA, Lim JI. Aminoglycoside toxicity in the treatment of endophthalmitis. The aminoglycoside Toxicity Study Group. Arch Ophthalmol. 1994; 112:48-53.

Kampougeris G,Antoniadou A, Kavouklis E, Chryssouli C, Giamarellou H. humour after oral administration Penetration of moxifloxacin into the human aqueous. Br J Ophthalmol. 2005; 89: 628-31

Campochiano Pa, Green WR. Toxicity of intravitreous ceftazidime in primate retina. Arch Ophthalmol. 1992; 10: 1625-9.

Cannon JO, Fiscella R, Pattharachayakul S, Garey KW, De Alba F, Piscitelli S, et al. Comparative toxicity and concentrations of intravitreal amphotericin B formulations in a rabbit model. Invest Ophthalmol Vis Sci. 2003; 44:2112-7.

Taban M, Behrens A, Newcomb RL, Nobe MY, Sacdi G, Sweet PM, et al. Acute endophthalmitis following cataract surgery: a systematic review of the literature. Arch Ophthalmol. 2005; 123:613-20.

Li J, Morlet N, Ng J, Semmens JB, Knuiman MW, EPSWA. Significan nonsurgical Risk Factors for Endophthalmitis after Cataract Surgery: EPSWA Fourth Report. Invest Ophthalmol Vis Sci. 2004; 45:1321–28.

McDonnell PJ, Taban M, Sarayba M, Rao B, Zhang J, Schiffman R, et al. Dynamic morphology of clear corneal cataract incisions. Ophthalmology. 2003; 110:2342-8.

Taban M, Saryba, Ignacio TS, Behrens A, McDonnell PJ. Ingress of India Ink into anterior chamber through sutureless clear corneal caataract wounds. Arch Ophthalmol. 2005; 123:643-8.

Vasavada AR, Praveen MR, Pandita D, Gajjar DU, Vasavada VA , Vasavada VA , et al. Effect of stromal hydration of clear corneal incisions: quantifying ingress of trypan blue into the anterior chamber after phacoemulsification. J Cataract Refract Surg. 2007; 33:623-7

Mayer E, Cadman D, Ewings P, Twomey JM, Gray RM, Claridge KG, et al. A 10 year retrospective survey of cataract surgery and endophthalmitis in a single eye unit: injectable lenses lower the incidence of endophthalmitis. Br J Ophthalmol. 2003; 87: 867-9.

Montan P, Lundström M, Stenevi U, Thorburn W. Endophtalmitis following cataract surgery in Sweden. The 1998 national prospective survey. Acta Ophthalmol Scand. 2002; 80: 258-61.

Microbiologic factors and visual outcome in the endophthalmitis vitrectomy study. Am J Ophthalmol 1996; 122: 830-46.

Narang S, Gupta A, Gupta V, Dogra MR, Ram J, Pandav SS, et al. Fungal endophthalmitis following cataract surgery: clinical presentation, microbiological spectrum, and outcome. Am J Ophthalmol. 2001; 132: 609-17.

Kunimoto DY,Das T, Sharma S, Jalali S, Majji AB , Gopinathan U, et al. Microbiologic spectrum and susceptibility of isolates: part I. Postoperative endophthalmitis. Endophthalmitis Research Group. Am J Ophthalmol. 1999; 128: 240-2.

Speaker MG, Menikoff JA. Prophylaxis of endophthalmitis with topical povidone-iodine. Ophthalmologty. 1991; 98: 1769-75.

Trinavarat A, Atchaneeyasakul LO, Nopmaneejumruslers C, Inson K. Reduction of endophthalmitis rate after cataract surgery with preoperative 5% povidone-iodine. Dermatology 2006; 212 (suppl 1):35-40.

Results of the Endophthalmitis Vitrectomy Study. A randomized trial of immediate vitrectomy and of intravenous antibiotics for the treatment of postoperative bacterial endophthalmitis. Endophthalmitis Vitrectomy Study Group. Arch Ophthalmol. 1995; 113: 1479-96.

Hariprasad SM, Mieler WF, Holz ER. Vitreous and Aqeous Penetration of Orally Administered Gatifloxacin in Humans. Arch Ophthalmol. 2003; 121:345-50.

García-Sáenz MC, Arias-Puente A, Fresnadillo- Martínez MJ, Carrasco-Font C . Human aqueous humor levels of oral ciprofloxacin, levofloxacin, and moxifloxacin. J Cataract Refract Surg. 2001; 27:1969-74.

Deramo VA, Fastenberg DM, Udell IJ. Acute Endophthalmitis in Eyes Treated Prophylactically with Gatifloxacin and Moxifloxacin. Am J Ophthalmol. 2006; 142: 721-5.

Solomon R, Donnenfeld ED, Perry HD, Snyder RW, Nedrud C, Stein J, et al. Penetration of topically applied gatifloxacin 0.3%, moxifloxacin 0.5%, and ciprofloxacin 0.3% into the aqueous humor. Ophthalmology. 2005; 112: 466-469.

Beigi B, Westlake W, Chang B, Marsh C, Jacob J, Riordan T. The effect of intracameral, per-operative antibiotics on microbial contamination of anterior chamber aspirates during phacoemulsification. Eye 1998; 12 (Pt 3a): 390-4.

Axer-Siegel R, Stiebel-Kalish H, Rosenblatt I, Strassmann E, Yassur Y, Weinberger D. Cystoid macular edema after cataract surgery with intraocular vancomycin. Ophthalmology. 1999; 106; 1660-64.

ESCRS Endophthalmitis Study Group. Prophylaxis of posoperative endophthalmitis following cataract surery. Results of the ESCRS multicenter study and identification of risk factors. J Caract Refract Surg. 2007; 33: 978-88.

Cooper BA, Holekamp NM, Bohigian G, Thompson PA. Case-control study of endophthalmitis after cataract surgery comparing scleral tunnel and clear corneal wounds. Am J Ophthalmol. 2003; 136: 300-5.

Essex RW, Yi Q, Charles PG, Allen PJ. Post-traumatic endophthalmitis. Ophthalmology. 2004; 111:2015–22.

Ariyasu RG, Kumar S, LaBree LD, Wagner DG, Smith RE. Microorganisms cultured from the anterior chamber of ruptured globes at the time of repair. Am J Ophthalmol. 1995; 119:181-188.

Rubsamen PE, Cousins SW, Martinez JA. Impact of cultures on management decisions following surgical repair of penetrating ocular trauma. Ophthalmic Surg Lasers. 1997; 28:43–49.

Thompson WS, Rubsamen PE , Flynn HW Jr, Schiffman J, Cousins SW. Endophthalmitis after penetrating trauma. Risk factors and visual acuity outcomes. Ophthalmology. 1995;102:1696-1701.

Lieb DF, Scott IU, Flynn HW Jr,Miller J, Feuer WJ. Open globe injuries with positive intraocular cultures: factors influencing final visual acuity outcomes. Ophthalmology. 2003;110:1560-6.

Kunimoto DY, Das T, Sharma S, Jalali S, Majji AB, Gopinathan U, et al. Microbiologic Spectrum and Susceptibility of Isolates: Part II. Posttraumatic Endophthalmitis. Am J Ophthalmol. 1999;128: 242-4.

Narang S, Gupta V, Gupta A, Dogra MR, Pandav SS, Das S. Role of prophylactic intravitreal antibiotics in open globe injuries. Indian J Ophthalmol. 2003;51:39-44.

Soheilian M, Rafati N, Peyman GA. Prophylaxis of acute posttraumatic bacterial endophthalmitis with or without combined intraocular antibiotics: a prospective, double-masked randomized pilot study. Int Ophthalmol. 2001; 24: 323-30.

Soheilian M, Rafati N, Mohebbi MR, Yazdani S, Habibabadi HF, Feghhi M, et al. Prophylaxis of acute posttraumatic bacterial endophthalmitis: a multicenter, randomized clinical trial of intraocular antibiotic injection, report 2. Arch Ophthalmol. 2007;125:460-5.

Das T, Jalali S, Gothwal VK, Sharma S, Naduvilath TJ. Intravitreal dexamethasone in exogenous bacterial endophthalmitis: results of a prospective randomised study. Br J Ophthalmol. 1999; 83(9):1050-5.

Shrader SK, Band JD, Lauter CB, Murphy P. The clinical spectrum of endophthalmitis: incidence, predisposing factors, and features influencing outcome. J Infect Dis. 1990; 162:115–120.

Jackson TL, Eykyn SJ, Graham EM, Stanford MR . Endogenous bacterial endophthalmitis: a 17-year prospective series and review of 267 reported cases. Surv Ophthalmol. 2003; 48: 403-23.

Fang CT, Lai SY, Yi WC, Hsuel PR, Liu KL, Chang SC. Klebsiella pneumoniae Genotype K1: An Emerging Pathogen That Causes Septic Ocular or Central Nervous System Complications from Pyogenic Liver Abscess. Clin Infect Dis. 2007; 45:284-93.

Schiedler V, Scott IU, Flynn HW, Davis JL, Benz MS, Miller D. Culture-proven endogenous endophthalmitis: clinical features and visual acuity outcomes. Am J Ophthalmol. 2004; 137: 725-31.

Krishna R, Amuh D, Lowder CY, Gordon SM, Adal KM, Hall G. Should all patients with candidaemia have an ophthalmic examination to rule out ocular candidiasis?. Eye. 2000; 14(Pt 1): 30-4.

Rao NA, Hidayat AA. Endogenous mycotic endophthalmitis: variations in clinical and histopathologic changes in candidiasis compared with aspergillosis. Am J Ophthalmol 2001; 132: 244-51.

Pappas PG, Rex JH, Karchmer AW, Sobel J, Edwards JE, Hadley S, et al. Guidelines for treatment of candidiasis. Clin Infect Dis 2004; 38: 161-89.58.

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Cómo citar

Cortés, J. A., & Cortés-Luna, C. F. (2008). Uso de antibióticos en endoftalmitis infecciosa. Revista De La Facultad De Medicina, 56(3), 245-256. https://revistas.unal.edu.co/index.php/revfacmed/article/view/14878

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Derechos de autor 2008 Revista de la Facultad de Medicina

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Esta obra está bajo una licencia Creative Commons Reconocimiento 3.0 Unported.

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