Revista Colombiana de Química

Koehn, F.; Carter, G. T. The Evolving Role of Natural Products in

Drug Discovery. Nat. Rev. Drug Discov. 2005. 4: 206–220.

Salvador, J.; Moreira, V. Highlights of Natural Products in Prostate

Cancer Drug Discovery. In prostate cancer; 2011; pp 463–482.

Nirmala, M. J.; Samundeeswari, A.; Sankar, P. D. Natural Plant Resources in Anti-Cancer Therapy. Res. plant Biol. 2011.1(3): 1–14.

Kumar, P.; Mishra, S.; Malik, A.; Satya, S. Compositional Analysis

and Insecticidal Activity of Eucalyptus Globulus (family: Myrtaceae)

Essential Oil against Housefly (Musca Domestica). Acta Trop.

122(2): 212–218.

Batish, D. R.; Singh, H. P.; Setia, N.; Kaur, S.; Kohli, R. K. Chemical

Composition and Inhibitory Activity of Essential Oil from Decaying

Leaves of Eucalyptus Citriodora. Z. Naturforsch. C. 2006. 61 (1-2):

–56.

Hase, P.; Digraskar, S.; Ravikanth, K.; Dandale, M.; Maini, S. Management of Subclinical Mastitis with Mastilep Gel and Herbal Spray (AV / AMS / 15 ). 2013. 2(4): 64–67.

Raut, J. S.; Karuppayil, S. M. A Status Review on the Medicinal Properties of Essential Oils. Ind. Crops Prod. 2014. 62: 250–264.

Silva, J.; Abebe, W.; Sousa, S. M.; Duarte, V. G.; Machado, M. I. L.;

Matos, F. J. A. Analgesic and Anti-Inflammatory Effects of Essential

Oils of Eucalyptus. J. Ethnopharmacol. 2003. 89(2-3): 277–283.

Luqman, S.; Dwivedi, G. R.; Darokar, M. P.; Kalra, A.; Khanuja, S. P. S.

Antimicrobial Activity of Eucalyptus Citriodora Essential. Int. J. Essent.

Oil Ther. 2008. 2: 69–75.

Singh, H. P.; Kaur, S.; Negi, K.; Kumari, S.; Saini, V.; Batish, D. R.;

Kohli, R. K. Assessment of in Vitro Antioxidant Activity of Essential

Oil of Eucalyptus citriodora (lemon-Scented Eucalypt; Myrtaceae)

and Its Major Constituents. LWT–Food Sci. Technol. 2012. 48(2):

–241.

Batish, D. R.; Singh, H. P.; Kohli, R. K.; Kaur, S. Eucalyptus Essential

Oil as a Natural Pesticide. For. Ecol. Manage. 2008. 256(12): 2166–

Gomes, M. R.; Felzenszwalb, I.; Paumgartten, F. J. R. Mutagenicity

Testing of Camphor, 1,8-Cineole, Citral, Citronellal, Menthol and

Terpineol with the Salmonella/microsome Assay. Genet. Toxicol. Environ. Mutagen. 1998. 416: 129–136.

Burt, S. Essential Oils: Their Antibacterial Properties and Potential

Applications in Foods. Int. J. Food Microbiol. 2004. 94(3): 223–253.

Victoria, F. N.; Radatz, C. S.; Sachini, M.; Jacob, R. G.; Alves, D.;

Savegnago, L.; Perin, G.; Motta, A. S.; Silva, W. P.; Lenardão, E. J.

Further Analysis of the Antimicrobial Activity of Α-Phenylseleno

Citronellal and Α-Phenylseleno Citronellol. Food Control. 2012.

(1): 95–99.

Dispersyn, G.; Nuydens, R.; Connors, R.; Borgers, M.; Geerts, H.

Bcl-2 Protects against FCCP-Induced Apoptosis and Mitochondrial

Membrane Potential Depolarization in PC12 Cells. Biochim. Biophys.

Acta–Gen. Subj. 1999. 1428(2-3): 357–371.

Jordán, J.; Ceña, V.; Prehn, J. H. M. Mitochondrial Control of Neuron Death and Its Role in Neurodegenerative Disorders. J. Physiol.

Biochem. 2003. 59(2): 129–141.

Cullen, K. J.; Yang, Z.; Schumaker, L.; Guo, Z. Mitochondria as a

Critical Target of the Chemotheraputic Agent Cisplatin in Head and

Neck Cancer. J. Bioenerg. Biomembr. 2007. 39(1): 43–50.

Krähenbühl, S. Mitochondria: Important Target for Drug Toxicity?

J. Hepatol. 2001. 34(2): 334–336.

Smith, R. A.; Hartley, R. C.; Cochemé, H. M.; Murphy, M. P. Mitochondrial Pharmacology. Trends Pharmacol. Sci. 2012. 33(6):

–352.

Duh, P. Der; Chen, Z. T.; Lee, S. W.; Lin, T. P.; Wang, Y. T.; Yen,

W. J.; Kuo, L. F.; Chu, H. L. Antiproliferative Activity and Apoptosis

Induction of Eucalyptus citriodora Resin and Its Major Bioactive

Compound in Melanoma B16F10 Cells. J. Agric. Food Chem. 2012.

: 7866–7872.

Stashenko, E. E.; Jaramillo, B. E.; Martínez, J. R. Analysis of Volatile

Secondary Metabolites from Colombian Xylopia Aromatica (Lamarck)

by Different Extraction and Headspace Methods and Gas

Chromatography. J. Chromatogr. A. 2004. 1025: 105–113.

Voss, D. O.; Campello, A. P.; Bacila, M. The Respiration Chain and

the Oxidative Phosphorylation of Rat Brain Mitochondria. Biochem.

Biophys. Res. Commun. 1961. 4(1), 48–61.

Bradford, M. M. A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding. Anal. Biochem. 1976. 72: 248–254.

Singer, T. Determination of the Activity of Succinate, NADH, Choline, and a-Glycerophosphate Dehydrogenases. Methods Biochem.

Anal. 1974. 22: 123–175.

Somlo, M. Induction Des Lactico-Cytochrome c Reductases (d-et

L-) de La Levure Aerobie Par Les Lactates (d- et L-). Biochim. Biophys.

Acta–Gen. Subj. 1965. 97(2): 183–201.

Mason, T. L.; Poyton, R.; Wharton, D. C. Cytochrome c Pxidase

Fron Bakers’ Yeast. J. Biol. Chem. 1973. 248(4): 1346–1354.

Pullman, M. E.; Penefsky, H. S.; Datta, A.; Racker, E. Partial Resolution of the Enzymes Catalyzing Oxidative Phosphorylation: Purification and Properties of Souble, Dinitrophenol-Stimulated Adenosine Triphosphatase. J. Biol. Chem. 1960. 235: 3322–3329.

Dickman, S. R.; Bray, H. Colorimetric Determination of Phosphate

Preparation of Reagents. Methods. 1940. 12(11): 665–668.

To, M.-S.; Aromataris, E. C.; Castro, J.; Roberts, M. L.; Barritt, G.

J.; Rychkov, G. Y. Mitochondrial Uncoupler FCCP Activates Proton

Conductance but Does Not Block Store-Operated Ca(2+) Current

in Liver Cells. Arch. Biochem. Biophys. 2010. 495(2): 152–158.

Cristiane, M.; D’Arrigo, M.; Mandalari, G.; Castelli, F.; Sarpietro,

M.; Micieli, D.; Venuti, V.; Bisignano, G.; Saija, A.; Trombetta, D.

Interaction of Four Monoterpenes Cointained in Essential Oil with

Model Membranes: Implications for Their Antibacterial Activity. J.

Agric. Food Chem. 2007. 55: 6300–6308.

Pires, A. D. R. A.; de Oliveira, M. B. M.; Echevarria, A.; Silva, E. F.;

Rocha, M. E. M.; Carnieri, E. G. S.; Martinez, G. R.; Noleto, G. R.;

Cadena, S. M. S. C. Comparative Study of the Effects of 1,3,4-Thiadiazolium Mesoionic Derivatives on Energy-Linked Functions of

Rat Liver Mitochondria. Chem. Biol. Interact. 2010. 186(1): 1–8.

Han, Y. H.; Kim, S. H.; Kim, S. Z.; Park, W. H. Carbonyl Cyanide

P-(trifluoromethoxy) Phenylhydrazone (FCCP) as an O2(*-) Generator

Induces Apoptosis via the Depletion of Intracellular GSH Contents

in Calu-6 Cells. Lung Cancer. 2009. 63(2): 201–209.

Vidau, C.; González-Polo, R. A.; Niso-Santano, M.; Gómez-Sánchez,

R.; Bravo-San Pedro, J. M.; Pizarro-Estrella, E.; Blasco, R.; Brunet, J.-

L.; Belzunces, L. P.; Fuentes, J. M. Fipronil Is a Powerful Uncoupler

of Oxidative Phosphorylation That Triggers Apoptosis in Human

Neuronal Cell Line SHSY5Y. Neurotoxicology. 2011. 32(6): 935–943.

Pardo-Andreu, G. L.; Nuñez, Y.; Tudella, V. G.; Cuesta-Rubio, O.;

Rodrigues, F. P.; Pestana, C. R.; Uyemura, S. A.; Leopoldino, A. M.;

Alberici, L. C.; Curti, C. The Anti-Cancer Agent Nemorosone Is a

New Potent Protonophoric Mitochondrial Uncoupler. Mitochondrion.

11(2): 255–263.

Kantrow, S. P.; Piantadosi, C. A. Release of Cytochrome c from Liver Mitochondria during Permeability Transition. Biochem. Biophys.

Res. Commun. 1997. 232(3): 669–671.

Morin, D.; Pires, F.; Plin, C.; Tillement, J. P. Role of the Permeability

Transition Pore in Cytochrome C Release from Mitochondria during

Ischemia-Reperfusion in Rat Liver. Biochem. Pharmacol. 2004.

(10): 2065–2073.

Bhagat, M.; Sharma, V.; Saxena, A. K. Anti-Proliferative Effect of

Leaf Extracts of Eucalyptus Citriodora against Human Cancer Cells in Vitro and in Vivo. Indian J. Biochem. Biophys. 2012. 49(December):

–457.

Azzone, G. F.; Zoratti, M.; Petronilli, V.; Pietrobon, D. The Stoichiometry of H+ Pumping in Cytochrome Oxidase and the Mechanism of Uncoupling. J. Inorg. Biochem. 1985. 23(3-4): 349–356.

Paradies, G.; Ruggiero, F. M.; Petrosillo, G.; Quagliariello, E. Enhanced Cytochrome Oxidase Activity and Modification of Lipids

in Heart Mitochondria from Hyperthyroid Rats. Biochim. Biophys.

Acta–Mol. Basis Dis. 1994. 1225(2): 165–170.

Shamoto, M. N.; Wakako M. M. Oxidative Stress in Mitochondria:

The Involvement in Neurodegenerative Diseases. In; 2005; pp

–444.

Riederer, P.; Mandel, M. Y. S. Profiling in Parkinson’s Disease: In;

; pp 62–76.

Maruszak, A.; Żekanowski, C. Mitochondrial Dysfunction and

Alzheimer’s Disease. Prog. Neuropsychopharmacol. Biol. Psychiatry.

35(2): 320–330.

Du, J.; Ma, M.; Zhao, Q.; Fang, L.; Chang, J.; Wang, Y.; Fei, R.; Song,

X. Mitochondrial Bioenergetic Deficits in the Hippocampi of Rats

with Chronic Ischemia-Induced Vascular Dementia. Neuroscience.

231: 345–352.

Atamna, H.; Kumar, R. Protective Role of Methylene Blue in

Alzheimer’s Disease via Mitochondria and Cytochrome c Oxidase.

J. Alzheimers. Dis. 2010. 20 Suppl 2, S439–S452.

Atamna, H.; Nguyen, A.; Schultz, C.; Boyle, K.; Newberry, J.; Kato,

H.; Ames, B. N. Methylene Blue Delays Cellular Senescence and Enhances Key Mitochondrial Biochemical Pathways. FASEB J. 2008.

(3): 703–712.

Siddique, Y. H.; Mujtaba, S. F.; Jyoti, S.; Naz, F. GC-MS Analysis

of Eucalyptus Citriodora Leaf Extract and Its Role on the Dietary

Supplementation in Transgenic Drosophila M