Publicado

2016-01-01

Método extendido de Hildebrand en la estimación de la solubilidad de algunas sulfonamidas estructuralmente relacionadas en mezclas etanol + agua

Extended Hildebrand solubility approach applied to some structurally related sulfonamides in ethanol + water mixtures

Palabras clave:

sulfonamides, ethanol, binary mixtures, extended Hildebrand solubility approach, Hildebrand solubility parameter (es)
sulfonamides, ethanol, binary mixtures, extended Hildebrand solubility approach, Hildebrand solubility parameter (en)

Autores/as

  • Daniel R. Delgado Universidad Cooperativa de Colombia
  • María Á. Peña Universidad de Alcalá
  • Fleming Martínez Universidad Nacional de Colombia

Se aplicó el Método Extendido de Solubilidad de Hildebrand (MESH) al estudio de la solubilidad de sulfadiazina, sulfamerazina y sulfametazina en mezclas binarias etanol + agua a 298,15 K. Se utilizaron valores reportados de solubilidad en equilibrio y algunas propiedades fisicoquímicas de fusión de estos compuestos. Se obtuvo una adecuada capacidad predictiva del MESH (con desviaciones promedio menores del 3,0 %) al utilizar modelos polinómicos regulares de cuarto orden relacionando el parámetro de interacción W con el parámetro de solubilidad de Hildebrand de las mezclas solventes. El carácter predictivo del MESH fue de magnitud semejante al que se obtuvo calculando esta propiedad directamente, donde se utilizó una regresión empírica regular de cuarto orden de la solubilidad experimental logarítmica de los fármacos en función del parámetro de solubilidad de las mezclas disolventes.

Extended Hildebrand Solubility Approach (EHSA) was applied to evaluate the solubility of sulfadiazine, sulfamerazine, and sulfamethazine in some ethanol + water mixtures at 298.15 K. Reported experimental equilibrium solubilities and some fusion properties of these drugs were used for the calculations. In particular, a good predictive character of EHSA (with mean deviations lower than 3.0%) has been found by using regular polynomials in order four correlating the interaction parameter W with the Hildebrand solubility parameter of solvent mixtures without drug. However, the predictive character of EHSA was the same as that obtained by direct correlation of drug solubilities with the same descriptor of polarity of the cosolvent mixtures.

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